Gestational changes in electrolyte transport, electrical activity, and permeability of the porcine placenta

Rice, G. E., Dantzer, V., Madsen, M. T. and Skadhauge, E. (1991) Gestational changes in electrolyte transport, electrical activity, and permeability of the porcine placenta. Journal of Comparative Physiology B, 161 2: 189-198. doi:10.1007/BF00262883


Author Rice, G. E.
Dantzer, V.
Madsen, M. T.
Skadhauge, E.
Title Gestational changes in electrolyte transport, electrical activity, and permeability of the porcine placenta
Journal name Journal of Comparative Physiology B   Check publisher's open access policy
ISSN 0174-1578
1432-136X
Publication date 1991-01-01
Year available 1991
Sub-type Article (original research)
DOI 10.1007/BF00262883
Open Access Status Not yet assessed
Volume 161
Issue 2
Start page 189
End page 198
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
The electrolyte transport capacities of the porcine placenta and fetal membranes (amnion, chorion, and allantois) during gestation (47-112 days) were assessed in vitro and in the absence of electrochemical, osmotic, or hydrostatic driving forces. Net transmural transport of 22Na and 36Cl across sections of porcine allantochorion-endometrium (ALCE), amniochorionendometrium (AMCE), and allantoamnion (AA) mounted in Ussing chambers could not be detected at any stage of gestation. 2. These tissues were characterised throughout gestation by low electrical potential difference (PD; <5 mV, fetal side positive with respect to maternal side) and short circuit current (SCC; <16 μA · cm-1) which were amiloride and iodoacetate sensitive. 3. A periparturitent reversal in the polarity of PD to fetal side negative and a change in the direction of the SCC was observed in tissues obtained from sows (n=3) at 111-112 day gestation. These changes were accompanied by a 73% increase in electrical resistance (R) and a 2-10-fold decrease in the permeability of tissues to Na and Cl. 4. Morphological studies revealed a decrease in the thickness of allantoamnion and a decrease in the height of epithelia from ALCE, AMCE, and AA during gestation, indicating a decrease in activity. These morphological changes only partly explained the pre-term electrophysiological changes in these tissues.
Keyword Physiology
Zoology
Physiology
Zoology
PHYSIOLOGY
ZOOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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