Multicellular spheroids in ovarian cancer metastases: Biology and pathology

Shield, Kristy, Ackland, M. Leigh, Ahmed, Nuzhat and Rice, Gregory E. (2009) Multicellular spheroids in ovarian cancer metastases: Biology and pathology. Gynecologic Oncology, 113 1: 143-148. doi:10.1016/j.ygyno.2008.11.032


Author Shield, Kristy
Ackland, M. Leigh
Ahmed, Nuzhat
Rice, Gregory E.
Title Multicellular spheroids in ovarian cancer metastases: Biology and pathology
Journal name Gynecologic Oncology   Check publisher's open access policy
ISSN 0090-8258
1095-6859
Publication date 2009-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ygyno.2008.11.032
Volume 113
Issue 1
Start page 143
End page 148
Total pages 6
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to treat is that the mechanism of dissemination is unusual. EOC dissemination characteristically involves local invasion of pelvic and abdominal organs. Unlike many epithelial cancers, initial dissemination rarely requires the vasculature, although the vasculature is often implicated in the advanced stages of disease. Recently, it has become apparent that aggregates of malignant cells (spheroids) contained within malignant ascites represent a significant impediment to efficacious treatment of late stage EOC. In vivo, spheroids are present in the malignant ascites of EOC patients, while in vitro cultured spheroids are capable of tumorgenesis in vivo and display a reduced response to chemotherapeutic drugs when compared to monolayers. A major problem associated with the current generation of chemotherapy agents is that they do not address the anchorage- and vascular-independent growth conditions associated with a 3-dimensional structure that has formed and/or grown in suspension. Thus, spheroid formation may represent a key component of platinum/taxane-sensitive recurrence. If this is correct, a better understanding of spheroid biology may contribute to the identification of new treatment opportunities for the sustained treatment of metastatic EOC. This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality.
Keyword Epithelial ovarian cancer
Spheroids
Metastasis
Chemotherapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Centre for Clinical Research Publications
 
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