Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses

Schaale, Kolja, Neumann, Jan, Schneider, Dagmar, Ehlers, Stefan and Reiling, Norbert (2011) Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses. Eurpopean Journal of Cell Biology, 90 6 - 7: 553-559. doi:10.1016/j.ejcb.2010.11.004

Author Schaale, Kolja
Neumann, Jan
Schneider, Dagmar
Ehlers, Stefan
Reiling, Norbert
Title Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses
Journal name Eurpopean Journal of Cell Biology   Check publisher's open access policy
ISSN 0171-9335
Publication date 2011-06-01
Sub-type Article (original research)
DOI 10.1016/j.ejcb.2010.11.004
Volume 90
Issue 6 - 7
Start page 553
End page 559
Total pages 7
Place of publication Germany
Publisher Urban und Fischer Verlag
Language eng
Abstract Wnt proteins are secreted, palmitoylated glycoproteins with multiple functions in cell proliferation and migration as well as tissue organization. They are best known for their role in embryonic development and tissue homeostasis. In the last years, Wnt signaling was also shown to be involved in the regulation of inflammatory processes: Wnt5a is induced in human macrophages in response to mycobacteria and conserved bacterial structures and contributes to the regulation of pro-inflammatory cytokines via its receptor Frizzled (Fzd) 5. Wnt5a is also induced in other infectious and inflammatory diseases such as tuberculosis, sepsis, psoriasis, rheumatoid arthritis and atherosclerosis. In contrast, Wnt3a, a ligand of Fzd1, is constitutively expressed by bronchial epithelial cells and mediates anti-inflammatory effects on mycobacteria-infected macrophages via the Wnt/beta-Catenin signaling pathway. This pathway suppresses the activity of GSK3beta, a well known regulator of NF-kappaB-dependent gene transcription. Here we review recent data on immunomodulatory activities of Wnt proteins. Additional experiments using exogenous Wnt homologs further support the notion that TLR/NF-kappaB and Wnt signaling are functionally interconnected. © 2010 Elsevier GmbH.
Keyword Infection
Wnt signaling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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Created: Wed, 13 Jul 2011, 01:52:30 EST by Susan Allen on behalf of Institute for Molecular Bioscience