Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial

Gray, Paul, Kirby, Julie, Smith, Maree T., Cabot, Peter J., Williams, Bronwyn, Doecke, James and Cramond, Tess (2011) Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain, 152 6: 1279-1288. doi:10.1016/j.pain.2011.01.055

Author Gray, Paul
Kirby, Julie
Smith, Maree T.
Cabot, Peter J.
Williams, Bronwyn
Doecke, James
Cramond, Tess
Title Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial
Journal name Pain   Check publisher's open access policy
ISSN 0304-3959
Publication date 2011-06-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.pain.2011.01.055
Open Access Status DOI
Volume 152
Issue 6
Start page 1279
End page 1288
Total pages 10
Place of publication Netherlands
Publisher Elsevier BV
Language eng
Subject 2728 Clinical Neurology
2703 Anesthesiology and Pain Medicine
2808 Neurology
3004 Pharmacology
Abstract This randomised, double-blind, placebo-controlled trial assessed the efficacy and tolerability of pregabalin to alleviate the neuropathic component of moderate to severe burn pain. Patients aged 18 to 65 years admitted to a burns unit with a 5% or greater total body surface area burn injury were screened to participate in the trial. Using the Neuropathic Pain Scale (NPS), patients scoring 4 or higher on 'hot' pain or 'sharp' pain were invited to participate. Consenting patients were randomly assigned to receive pregabalin or placebo for 28 days with individual dose titration commencing at 75 mg twice daily to a maximum pregabalin dose of 300 mg twice daily. The primary outcome measure was the patients' daily response to the sharp and hot pain of the NPS. Secondary outcome measures included the remaining elements of the NPS, daily opioid requirement, length of hospital stay, pain at 6 months, and side effects of nausea, vomiting, drowsiness and giddiness. For patients administered pregabalin, the primary outcome measures hot (P = .01) and sharp (P = .04) pain were significantly reduced compared with those in patients administered placebo. Secondary outcome measures of itch, unpleasantness, surface pain, and procedural pain were significantly lower (P < .05) in the pregabalin group. Adverse effects were uncommon, with no difference between the treatment groups. There was no significant difference between the pregabalin and placebo treatment groups with respect to opioid consumption, duration of hospital stay, or pain at 6 months. Pregabalin was efficacious and well tolerated in patients after severe burn injury and whose pain was characterised by features of acute neuropathic pain. In this study, pregabalin was well tolerated and significantly reduced several elements of the neuropathic pain scale including hot pain, unpleasantness of the pain, surface pain, and itch, and also significantly reduced procedural pain. © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
Keyword Pain management
Burn injury
Randomised placebo-controlled trial
Neuropathic pain scale
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 07 Jul 2011, 00:49:30 EST by Charna Kovacevic on behalf of School of Pharmacy