Expression of a candidate sex-determining gene during mouse testis differentiation

Koopman, Peter, Munsterberg, Andre, Capel, Blanche, Vivian, Nigel and Lovell Badge, Robin (1990) Expression of a candidate sex-determining gene during mouse testis differentiation. Nature, 348 6300: 450-452. doi:10.1038/348450a0


Author Koopman, Peter
Munsterberg, Andre
Capel, Blanche
Vivian, Nigel
Lovell Badge, Robin
Title Expression of a candidate sex-determining gene during mouse testis differentiation
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 1990-11-01
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1038/348450a0
Volume 348
Issue 6300
Start page 450
End page 452
Total pages 3
Place of publication Hamps, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The development of a eutherian mammal as a male is a consequence of testis formation in the embryo, which is thought to be initiated by a gene on the Y chromosome. In the absence of this gene, ovaries are formed and female characteristics develop. Sex determination therefore hinges on the action of this testis-determining gene, known as Tdy in mice and TDF in humans. In the past, several genes proposed as candidates for Tdy/TDF have subsequently been dismissed on the grounds of inappropriate location or expression. We have recently described a candidate for Tdy, which maps to the minimum sex-determining region of the mouse Y chromosome. To examine further the involvement of this gene, Sry, in testis development, we have studied its expression in detail. Fetal expression of Sry is limited to the period in which testes begin to form. This expression is confined to gonadal tissue and does not require the presence of germ cells. Our observations strongly support a primary role for Sry in mouse sex determination.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: Institute for Molecular Bioscience - Publications
 
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