The UTX gene escapes X inactivation in mice and humans

Greenfield, Andy, Carrel, Laura, Pennisi, David, Philippe, Christophe, Quaderi, Nandita, Siggers, Pamela, Steiner, Kirsten, Tam, Patrick P. L., Monaco, Anthony P., Willard, Huntington F. and Koopman, Peter (1998) The UTX gene escapes X inactivation in mice and humans. Human Molecular Genetics, 7 4: 737-742. doi:10.1093/hmg/7.4.737

Author Greenfield, Andy
Carrel, Laura
Pennisi, David
Philippe, Christophe
Quaderi, Nandita
Siggers, Pamela
Steiner, Kirsten
Tam, Patrick P. L.
Monaco, Anthony P.
Willard, Huntington F.
Koopman, Peter
Title The UTX gene escapes X inactivation in mice and humans
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
Publication date 1998-04-01
Year available 1998
Sub-type Article (original research)
DOI 10.1093/hmg/7.4.737
Open Access Status Not yet assessed
Volume 7
Issue 4
Start page 737
End page 742
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 1312 Molecular Biology
1311 Genetics
2716 Genetics (clinical)
Abstract We recently have identified a ubiquitously transcribed mouse Y chromosome gene, Ufy, which encodes a tetratricopeptide repeat (TPR) protein. A peptide derived from the UTY protein confers H-Y antigenicity on male cells. Here we report the characterization of a widely transcribed X-linked homologue of Uty, called Utx, which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11.2. Given that Uty is ubiquitously transcribed, we assayed for Utx expression from the inactive X chromosome (Xi) in mice and found that Utx escapes X chromosome inactivation. Only Smcx and the pseudoautosomal Sts gene on the mouse X chromosome have been reported previously to escape inactivation. The human UTX gene was also found to be expressed from Xi. We discuss the significance of these data for our understanding of dosage compensation of X-Y homologous genes in humans and mice.
Keyword Mouse Y-chromosome
Turner Syndrome
Smcx gene
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID TGM06S01
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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