Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization

Da Silva, Leonard, James, Daniel, Simpson, Peter T., Walker, Daniel, Vargas, Ana Cristina, Jayanthan, Janani, Lakhani, Sunil R. and McNicol, Anne Marie (2011) Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization. Endocrine Pathology, 22 2: 103-107. doi:10.1007/s12022-011-9154-y

Author Da Silva, Leonard
James, Daniel
Simpson, Peter T.
Walker, Daniel
Vargas, Ana Cristina
Jayanthan, Janani
Lakhani, Sunil R.
McNicol, Anne Marie
Title Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization
Journal name Endocrine Pathology   Check publisher's open access policy
ISSN 1046-3976
Publication date 2011-06-01
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s12022-011-9154-y
Open Access Status
Volume 22
Issue 2
Start page 103
End page 107
Total pages 5
Place of publication United States
Publisher Humana Press, Inc.
Language eng
Subject 2734 Pathology and Forensic Medicine
2712 Endocrinology, Diabetes and Metabolism
1310 Endocrinology
Abstract We report a follicular carcinoma of thyroid that showed a range of histologic appearances, with microfollicular, macrofollicular/pseudopapillary, oncocytic, and poorly differentiated areas. We used comparative genomic hybridization to detect the major DNA copy number changes in each component, in order to study the inter-relationships among them. All showed gains in 11q and 17q, suggesting that these were early events in the development of the tumor, and these were the only changes in the follicular component. The other components each showed additional gains and losses, some unique to one component. The oncocytic component showed most changes, including loss on 16q in the region of the E-cadherin gene. This was associated with reduced intensity of immunostaining for E-cadherin specifically in that component. No mutations in the E-cadherin gene were detected in this component. The demonstration that some DNA copy number changes are consistent across each component suggests that they are all clonally related. The additional chromosomal and immunohistochemical heterogeneity across the macrofollicular/pseudopapillary, oncocytic, and poorly differentiated components would be consistent with the emergence of subclones, possibly as part of tumor progression. © 2011 Springer Science+Business Media, LLC.
Keyword Chromosome
Comparative genomic hybridization
Follicular carcinoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
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Created: Thu, 23 Jun 2011, 01:48:00 EST by Dr Leonard Da Silva on behalf of School of Medicine