Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results

Bigio, Irving J., Bown, Stephen G., Briggs, Gavin, Kelley, Christine, Lakhani, Suni, Pickard, David, Ripley, Paul M., Rose, Ian G. and Saunders, Christobel (2000) Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. Journal of Biomedical Optics, 5 2: 221-228. doi:10.1117/1.429990

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Author Bigio, Irving J.
Bown, Stephen G.
Briggs, Gavin
Kelley, Christine
Lakhani, Suni
Pickard, David
Ripley, Paul M.
Rose, Ian G.
Saunders, Christobel
Title Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results
Journal name Journal of Biomedical Optics   Check publisher's open access policy
ISSN 1083-3668
Publication date 2000-04-01
Sub-type Article (original research)
DOI 10.1117/1.429990
Open Access Status File (Publisher version)
Volume 5
Issue 2
Start page 221
End page 228
Total pages 8
Place of publication Bellingham, WA, United States
Publisher S P I E - International Society for Optical Engineering
Language eng
Abstract We report on the first stages of a clinical study designed to test elastic-scattering spectroscopy, mediated by fiberoptic probes, for three specific clinical applications in breast-tissue diagnosis: (1) a transdermal-needle (interstitial) measurement for instant diagnosis with minimal invasiveness similar to fine-needle aspiration but with sensitivity to a larger tissue volume, (2) a hand-held diagnostic probe for use in assessing tumor/resection margins during open surgery, and (3) use of the same probe for real-time assessment of the `sentinel' node during surgery to determine the presence or absence of tumor (metastatic). Preliminary results from in vivo measurements on 31 women are encouraging. Optical spectra were measured on 72 histology sites in breast tissue, and 54 histology sites in sentinel nodes. Two different artificial intelligence methods of spectral classification were studied. Artificial neural networks yielded sensitivities of 69% and 58%, and specificities of 85% and 93%, for breast tissue and sentinel nodes, respectively. Hierarchical cluster analysis yielded sensitivities of 67% and 91%, and specificities of 79% and 77%, for breast tissue and sentinel nodes, respectively. These values are expected to improve as the data sets continue to grow and more sophisticated data preprocessing is employed. The study will enroll up to 400 patients over the next two years.
Keyword Elastic-scattering spectroscopy
Diffuse reflectance
Tissue spectroscopy
Optical diagnosis
Optical biopsy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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