Changing patterns of herpes simplex virus infection in neonates

Whitley, Richard J., Corey, Lawrence, Arvin, Ann, Mintz, Eric, Lakeman, Fred D., Sumaya, Ciro V., Wright, Peter F., Dunkle, Lisa M., Steele, Russell W., Soong, Seng-Jaw, Nahmias, Andre J., Alford, Charles A., Powell, Dwight A. and Sanjoaquin, Venusto San (1988) Changing patterns of herpes simplex virus infection in neonates. Journal of Infectious Diseases, 158 1: 109-116. doi:10.1093/infdis/158.1.109

Author Whitley, Richard J.
Corey, Lawrence
Arvin, Ann
Mintz, Eric
Lakeman, Fred D.
Sumaya, Ciro V.
Wright, Peter F.
Dunkle, Lisa M.
Steele, Russell W.
Soong, Seng-Jaw
Nahmias, Andre J.
Alford, Charles A.
Powell, Dwight A.
Sanjoaquin, Venusto San
Title Changing patterns of herpes simplex virus infection in neonates
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
Publication date 1988-07-01
Year available 1988
Sub-type Article (original research)
DOI 10.1093/infdis/158.1.109
Open Access Status Not yet assessed
Volume 158
Issue 1
Start page 109
End page 116
Total pages 8
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Abstract We compared the clinical presentation of 95 newborns with herpes simplex virus (HSV) infection from 1973 through 1981 (first period) with data from 196 newborns evaluated from 1982 through 1987(second period). There was a significant change in the presentation of infection in these infants. From the first to the second period, the frequency of disseminated disease decreased from 50.5% to 22.9%, whereas the frequency of skin, eye, and mouth (SEM) diseases increased from 17.9% to 43.4% (P < .001). The frequency of infants with central nervous system (CNS) disease remained relatively unchanged - 31.6% versus 33.7%. We also compared the demographic and clinical characteristics of the infants and their mothers. For neonates with CNS or disseminated infection, disease duration and frequency of prematurity were significantly decreased in the second period, as was the frequency of skin vesicles for newborns with SEM or disseminated infection. These changes are most likely the consequence of recognizing and treating SEM infection before its progression to more-severe disease.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID RR-032
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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