Development of specific cellular and humoral immune responses in children immunized with live rubella virus vaccine

Steele, Russell W., Hensen, Sally A., Vincent, Munroe M., Fuccillo, David A. and Bellanti, Joseph A. (1974) Development of specific cellular and humoral immune responses in children immunized with live rubella virus vaccine. Journal of Infectious Diseases, 130 5: 449-453. doi:10.1093/infdis/130.5.449


Author Steele, Russell W.
Hensen, Sally A.
Vincent, Munroe M.
Fuccillo, David A.
Bellanti, Joseph A.
Title Development of specific cellular and humoral immune responses in children immunized with live rubella virus vaccine
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 1974-01-01
Year available 1974
Sub-type Article (original research)
DOI 10.1093/infdis/130.5.449
Open Access Status Not yet assessed
Volume 130
Issue 5
Start page 449
End page 453
Total pages 5
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Formatted abstract
The development of cell-mediated immunity by 51Cr lymphocytotoxicity was measured over a 42-day period in 12 children immunized with live rubella virus vaccine (HPV-77-DE5) and was compared with the development in serum of hemagglutination inhibition antibody response to rubella. Cell-mediated immunity was detected as early as three days after immunization, reached a maximum between seven and 14 days, and declined slowly thereafter. Serum antibody was not detected until more than 14 days after immunization, and then it gradually increased. Two control children remained negative for both tests. An additional six children within the same age group, who presumably had been immunized or infected with rubella previously, had appreciable titers for cell-mediated immunity and hemagglutination inhibition. In comparing the immune responses according to birthweights, cell-mediated immunity was detected earlier in infants who were born at full term (> 2,500 g) than in those of low birthweight. A similar, but less striking, difference was the earlier development of humoral antibody in the full-term infants. The measurement of specific cell-mediated immunity to rubella virus by lymphocytotoxicity may provide a valuable in vitro marker of effectiveness of vaccine and of protective immunity to viral infection.
Keyword Immunology
Infectious Diseases
Microbiology
Immunology
Infectious Diseases
Microbiology
IMMUNOLOGY
INFECTIOUS DISEASES
MICROBIOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 16 Jun 2011, 21:56:24 EST by System User on behalf of School of Medicine