Transfer factor for the prevention of varicella-zoster infection in childhood leukemia

Steele, Russell W., Myers, Martin G. and Vincent, Monroe M. (1980) Transfer factor for the prevention of varicella-zoster infection in childhood leukemia. New England Journal of Medicine, 303 7: 355-359. doi:10.1056/NEJM198008143030702

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Author Steele, Russell W.
Myers, Martin G.
Vincent, Monroe M.
Title Transfer factor for the prevention of varicella-zoster infection in childhood leukemia
Journal name New England Journal of Medicine   Check publisher's open access policy
ISSN 0028-4793
1533-4406
Publication date 1980-01-01
Sub-type Article (original research)
DOI 10.1056/NEJM198008143030702
Open Access Status File (Publisher version)
Volume 303
Issue 7
Start page 355
End page 359
Total pages 5
Place of publication Boston, MA, United States
Publisher Massachusetts Medical Society
Language eng
Formatted abstract
Sixty-one patients with leukemia and no immunity to chickenpox were given dialyzable transfer factor or placebo and followed for 12 to 30 months in a double-blind trial designed to examine the clinical efficacy of transfer factor. Sixteen patients in the transfer-factor group and 15 in the placebo group were exposed to varicella zoster, and most of them had a rise in antibody titer. Chickenpox developed in 13 of 15 exposed patients in the placebo group but in only one of 16 in the transfer-factor froup (P = 1.3X10-5). In the patients treated with transfer factor and exposed to varicella without acquiring chickenpox the titer of antibody to varicella zoster was equal to that in the patients given placebo who became infected with chickenpox. Transfer factor converted negative results on skin tests for varicella zoster to positive in approximately half of the recipients. Passive immunization with dialyzable transfer factor appears useful in nonimmune persons.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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