Treatment of varicella-zoster meningoencephalitis with acyclovir - Demonstration of virus in cerebrospinal fluid by electron microscopy

Steele, R. W., Keeney, R. E., Bradsher, R. W., Moses, E. B. and Soloff, B. L. (1983) Treatment of varicella-zoster meningoencephalitis with acyclovir - Demonstration of virus in cerebrospinal fluid by electron microscopy. American Journal of Clinical Pathology, 80 1: 57-60.

Author Steele, R. W.
Keeney, R. E.
Bradsher, R. W.
Moses, E. B.
Soloff, B. L.
Title Treatment of varicella-zoster meningoencephalitis with acyclovir - Demonstration of virus in cerebrospinal fluid by electron microscopy
Journal name American Journal of Clinical Pathology   Check publisher's open access policy
ISSN 0002-9173
1943-7722
Publication date 1983-01-01
Year available 1983
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 80
Issue 1
Start page 57
End page 60
Total pages 4
Place of publication Birmingham, AL, United States
Publisher American Society for Clinical Pathology
Language eng
Abstract Disseminated varicella-zoster (V-Z) infection developed in three immunocompromised patients, with direct invasion of the central nervous system by virus. For two of these patients, diagnosis was confirmed by electron microscopic examination of cerebrospinal fluid (CSF) and detection of viral particles. Extensive immunologic evaluation demonstrated impairment of cellular immune function. All were treated with acyclovir at a dose of 1,500 mg/m2/day for 5-7 days. Peak and trough plasma levels of this antiviral agent were monitored during the course of therapy and were shown to be well above V-Z virustatic levels. Clinical response was noted by the third day of therapy. Vesicles and CSF were culture negative at termination of treatment. Administration of this high dose of acyclovir was not associated with hematologic, immunologic, hepatic, renal, or gastrointestinal toxicity as judged by frequent laboratory and clinical evaluation.
Keyword Pathology
Pathology
PATHOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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