Impaired cellular immunity to rubella virus in congenital rubella

Fuccillo, David A., Steele, Russell W., Hensen, Sally A., Vincent, Monroe M., Hardy, Janet B. and Bellanti, Joseph A. (1974) Impaired cellular immunity to rubella virus in congenital rubella. Infection and Immunity, 9 1: 81-84.

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Author Fuccillo, David A.
Steele, Russell W.
Hensen, Sally A.
Vincent, Monroe M.
Hardy, Janet B.
Bellanti, Joseph A.
Title Impaired cellular immunity to rubella virus in congenital rubella
Journal name Infection and Immunity
ISSN 1098-5522
Publication date 1974-01-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 9
Issue 1
Start page 81
End page 84
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Specific cell-mediated immunity (CMI) responses to rubella virus were studied in 12 children with documented congenital rubella syndrome employing a 51Cr lymphocytotoxicity microassay. Hemagglutination inhibition antibody was detected in 11 of the 12 children, with titers ranging from 1:4 to 1:128. CMI to rubella virus was demonstrated in only 3 of the 11 antibody-positive children. The 12th child was negative for both hemagglutination inhibition and CMI. Of the three children with a positive CMI response, two had histories of reinfection with rubella virus. These data suggest that congenital rubella infection produces an impaired CMI response which subsequently may be altered by reinfection with rubella virus. The lack of CMI in the presence of antibody and concurrent excretion of live virus in the child with documented congenital rubella infection suggest a factor to be explored in the pathogenesis of this disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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