Intrauterine herpes simplex virus infections

Hutto, Cecelia, Arvin, Ann, Jacobs, Richard, Steele, Russell, Stagno, Sergio, Lyrene, Raymond, Willett, Lynne, Powell, Dwight, Andersen, Richard, Werthammer, Joe, Ratcliff, Gilbert, Nahmias, Andre, Christy, Cynthia and Whitley, Richard (1987) Intrauterine herpes simplex virus infections. Journal of Pediatrics, 110 1: 97-101. doi:10.1016/S0022-3476(87)80298-6

Author Hutto, Cecelia
Arvin, Ann
Jacobs, Richard
Steele, Russell
Stagno, Sergio
Lyrene, Raymond
Willett, Lynne
Powell, Dwight
Andersen, Richard
Werthammer, Joe
Ratcliff, Gilbert
Nahmias, Andre
Christy, Cynthia
Whitley, Richard
Title Intrauterine herpes simplex virus infections
Journal name Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
Publication date 1987-01-01
Year available 1987
Sub-type Article (original research)
DOI 10.1016/S0022-3476(87)80298-6
Open Access Status Not yet assessed
Volume 110
Issue 1
Start page 97
End page 101
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Abstract Neonatal herpessimplexvirus (HSV) infection is usually acquired at birth, although a few infants have had findings suggestive of intrauterineinfection. We describe 13 babies who had clinical manifestations of intrauterine HSV infection, including skin lesions and scars at birth (12), chorioretinitis (eight), microcephaly (seven), hydranencephaly (five), and microphthalmia (two). All infants had combinations of these defects. Infection was proved by viral isolation in each case; all isolates were HSV-2. Two infants died during the first week of life; 10 of the surviving infants had severe neurologic sequelae, and one infant was blind. Four mothers experienced an apparent primary genital HSV infection, and one had recurrent infection, at varying times during gestation. The remaining women denied a history of symptoms of genital HSV infection. These findings indicate that intrauterine HSV infection can occur as a consequence of either primary or recurrent maternal infection and has severe consequences for the fetus.
Keyword Pediatrics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID NCI-13148
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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