Potential of immunomodulatory host defense peptides as novel anti-infectives

Easton, DM, Nijnik, A, Mayer, ML and Hancock, REW (2009) Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends in Biotechnology, 27 10: 582-590. doi:10.1016/j.tibtech.2009.07.004


Author Easton, DM
Nijnik, A
Mayer, ML
Hancock, REW
Title Potential of immunomodulatory host defense peptides as novel anti-infectives
Journal name Trends in Biotechnology   Check publisher's open access policy
ISSN 0167-7799
1879-3096
Publication date 2009-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tibtech.2009.07.004
Open Access Status Not yet assessed
Volume 27
Issue 10
Start page 582
End page 590
Total pages 9
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. Antimicrobial host defense peptides have been investigated for their potential as a new class of antimicrobial drugs. Recently their immunomodulatory activities have begun to be appreciated. Modulation of innate immunity by synthetic variants of host defense peptides, called innate defense regulators (IDRs), is protective without direct antimicrobial action. We discuss the potential and current limitations in exploiting the immunomodulatory activity of IDRs as a novel anti-infective pathway. IDRs show significant promise and current research is uncovering mechanistic information that will aid in the future development of IDRs for clinical use.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Veterinary Science Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 116 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 128 times in Scopus Article | Citations
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Created: Thu, 09 Jun 2011, 03:22:50 EST by Dr Donna M Easton on behalf of School of Veterinary Science