Neuropeptides and thymic hormones in the Xenopus thymus

Silva, Alberto B., Aw, Danielle and Palmer, Donald B. (2009) Neuropeptides and thymic hormones in the Xenopus thymus. Frontiers in Bioscience, 14 6: 1990-2003. doi:10.2741/3358

Author Silva, Alberto B.
Aw, Danielle
Palmer, Donald B.
Title Neuropeptides and thymic hormones in the Xenopus thymus
Formatted title
Neuropeptides and thymic hormones in the Xenopus thymus
Journal name Frontiers in Bioscience   Check publisher's open access policy
ISSN 1093-9946
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.2741/3358
Volume 14
Issue 6
Start page 1990
End page 2003
Total pages 14
Place of publication Albertson, NY, United States
Publisher Frontiers in Bioscience
Language eng
Formatted abstract
T-cell development is characterised by a complex series of events in the thymus, which results in the development of self-restricted immunocompetent lymphocytes. We have previously reported the expression of neuropeptides in the thymus of various species, highlighting the evolutionary importance of neuroendocrine interactions in thymocyte development. Despite the many physiological and functional similarities in their immune systems, no study has addressed the importance of neuropeptides and thymic hormones in T-cell development in Xenopus. Immunohistochemical analysis revealed that the neuropeptides substance P, neuropeptide Y, somatostatin, calcitonin gene related peptide, and vasoactive intestinal polypeptide and the thymic hormones thymosin alpha1, thymosin beta4, and thymopoietin are found in the Xenopus thymus. This was further corroborated by RT-PCR. Furthermore, double staining revealed that neuropeptides and thymic hormones are coexpressed within the epithelial cell component of the thymus. These results show that neuropeptides and thymic hormones are expressed in the thymus of Xenopus, and suggest that they are likely to play a role in T-cell development.
Keyword Neuropeptides
Thymic hormones
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 28 May 2011, 00:22:14 EST by Susan Allen on behalf of Institute for Molecular Bioscience