The effect of age on the phenotype and function of developing thymocytes

Aw, D., Da Silva, A. B. and Palmer, D. B. (2010). The effect of age on the phenotype and function of developing thymocytes. In: Proceedings of the Second Merial European Comparative Vaccinology Symposium : 'Vaccination Challenges in Ageing Populations'. Second Merial European Comparative Vaccinology Symposium : 'Vaccination Challenges in Ageing Populations', Prague, Czech Republic, (S45-S59). 13-15 May 2009. doi:10.1016/j.jcpa.2009.10.004


Author Aw, D.
Da Silva, A. B.
Palmer, D. B.
Title of paper The effect of age on the phenotype and function of developing thymocytes
Conference name Second Merial European Comparative Vaccinology Symposium : 'Vaccination Challenges in Ageing Populations'
Conference location Prague, Czech Republic
Conference dates 13-15 May 2009
Proceedings title Proceedings of the Second Merial European Comparative Vaccinology Symposium : 'Vaccination Challenges in Ageing Populations'   Check publisher's open access policy
Journal name Journal of Comparative Pathology   Check publisher's open access policy
Place of Publication Oxford, U.K.
Publisher Elsevier
Publication Year 2010
Year available 2009
Sub-type Fully published paper
DOI 10.1016/j.jcpa.2009.10.004
ISSN 0021-9975
1532-3129
Volume 142
Issue Supplement 1
Start page S45
End page S59
Total pages 15
Collection year 2011
Language eng
Formatted Abstract/Summary
The immune system declines with age leading to a progressive deterioration in the ability to respond to infection and vaccination. Age-associated thymic involution is one of the most recognized changes in the ageing immune system and is believed to be a major contributor towards immunosenescence; however, the precise mechanisms involved in age-associated thymic involution remain unclear. In order to gain further insight into the effect of ageing on T-cell development, steady-state thymopoiesis was studied in mice ranging from 1 to 18 months of age. There was a decrease in thymic cellularity with age, but the most dramatic loss occurred early in life. Although there were no alterations in the proportion of the major thymocyte subsets, there was a significant decline in the expression of other key molecules including CD3 and CD24. There was a decline in the ability of thymocytes from older mice to respond to mitogens, which was demonstrated by a failure to up-regulate expression of the activation marker CD69 and to enter the G2 - M phase of the cell cycle. This was concurrent with an increased resistance to apoptosis in thymocytes from aged animals. Together, these results suggest that T cells may be flawed even before exiting to the periphery and that this could contribute to the age-associated decline in immune function.
© 2009 Elsevier Ltd. All rights reserved.
Keyword Ageing
Apoptosis
Thymic involution
Thymopoiesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Available online 8 December 2009.

Document type: Conference Paper
Collections: Non HERDC
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Created: Wed, 25 May 2011, 22:30:50 EST by Susan Allen on behalf of Institute for Molecular Bioscience