What's new in osteoclast ontogeny?

Zheng, M.H., Nicholson, G.C. and Papadimitriou, J.M. (1991) What's new in osteoclast ontogeny?. Pathology Research and Practice, 187 1: 117-125.

Author Zheng, M.H.
Nicholson, G.C.
Papadimitriou, J.M.
Title What's new in osteoclast ontogeny?
Journal name Pathology Research and Practice   Check publisher's open access policy
ISSN 0344-0338
Publication date 1991-01-01
Sub-type Critical review of research, literature review, critical commentary
Open Access Status Not yet assessed
Volume 187
Issue 1
Start page 117
End page 125
Total pages 9
Place of publication Jena, Germany
Publisher Urban und Fischer
Language eng
Formatted abstract
The osteoclast (OC) is a multinuclear bone-resorbing cell which shares several characteristics with cells of the mononuclear phagocyte system. Unlike terminally differentiated macrophages, OCs possess specialized characteristics such as tartrate resistant acid phosphatase activity and the presence of calcitonin receptors. It appears that myeloid progenitor cells, probably granulocyte-macrophage colony-forming units, generate OC precursors which then differentiate and fuse into OCs under the regulation of osteotropic hormones, cytokines and other local factors. Parathyroid hormone and 1,25 dihydroxy Vitamin D3 induce both the formation and fusion of OC precursors, while calcitonin inhibits fusion. Osteoblasts also produce factor(s) which regulate OC precursor differentiation and therefore bone resorption; the nature of these factor(s), however, is unknown. In addition, the OC surface interacts specifically with a range of cellular and extracellular matrix-associated ligands which influence OC differentiation. The precise regulation of OC formation, however, is complex and awaits further investigation.
Keyword Osteoblast
Enzyme cytochemistry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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