Lifetime psychiatric disorders and body composition: A population-based study

Williams, Lana J., Pasco, Julie A., Henry, Margaret J., Jacka, Felice N., Dodd, Seetal, Nicholson, Geoffrey C., Kotowicz, Mark A. and Berk, Michael (2009) Lifetime psychiatric disorders and body composition: A population-based study. Journal of Affective Disorders, 118 1-3: 173-179. doi:10.1016/j.jad.2009.02.001

Author Williams, Lana J.
Pasco, Julie A.
Henry, Margaret J.
Jacka, Felice N.
Dodd, Seetal
Nicholson, Geoffrey C.
Kotowicz, Mark A.
Berk, Michael
Title Lifetime psychiatric disorders and body composition: A population-based study
Journal name Journal of Affective Disorders   Check publisher's open access policy
ISSN 0165-0327
Publication date 2009-11-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.jad.2009.02.001
Open Access Status Not yet assessed
Volume 118
Issue 1-3
Start page 173
End page 179
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Background: This study aimed to investigate the relationship between depressive and anxiety disorders and indices of adiposity, including body fat mass and percent body fat, as measured by dual energy X-ray absorptiometry. Methods: In this observational study of 979 randomly-selected women aged 20-93 years, psychiatric history was ascertained using a structured clinical interview (SCID-I/NP). Total body fat was assessed using dual-energy X-ray absorptiometry and weight, height and waist circumference were measured. Medication use and lifestyle factors were self-reported. Results: Those with a lifetime history of depression had increased fat mass (+ 7.4%) and percent body fat (+ 4.3%), as well as greater mean weight (+ 3.3%), waist circumference (+ 2.9%) and BMI (+ 3.5%) after adjustment for age, anxiety, alcohol consumption, physical activity and past smoking. Furthermore, those meeting criteria for a lifetime history of depression had a 1.7-fold increased odds of being overweight or obese (BMI ≥ 25), a 2.0-fold increased odds of being obese (BMI ≥ 30) and a 1.8-fold increased odds of having a waist circumference ≥ 80 cm. These patterns persisted after further adjustment for psychotropic medication use, smoking status and energy intake. No differences in any measures of adiposity were observed among those with anxiety disorders compared to controls. Limitations: There is potential for unrecognised confounding, interpretations are limited to women and a temporal relationship could not be inferred. Conclusions: Depression was associated with greater adiposity. The difference in body fat mass was numerically greater than differences in indirect measures of adiposity, suggesting that the latter may underestimate the extent of adiposity in this population.
Keyword Depressive disorders
Anxiety disorders
Body composition
Psychiatric epidemiology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 251638
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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