Lifestyle factors fail to explain the variation in plasma leptin concentrations in women

De Silva, Andrea, De Courten, Maximilian, Zimmet, Paul, Nicholson, Geoff, Kotowicz, Mark, Pasco, Julie and Collier, Greg R. (1998) Lifestyle factors fail to explain the variation in plasma leptin concentrations in women. Nutrition, 14 9: 653-657. doi:10.1016/S0899-9007(98)00065-3

Author De Silva, Andrea
De Courten, Maximilian
Zimmet, Paul
Nicholson, Geoff
Kotowicz, Mark
Pasco, Julie
Collier, Greg R.
Title Lifestyle factors fail to explain the variation in plasma leptin concentrations in women
Journal name Nutrition   Check publisher's open access policy
ISSN 0899-9007
Publication date 1998-09-01
Year available 1998
Sub-type Article (original research)
DOI 10.1016/S0899-9007(98)00065-3
Open Access Status Not Open Access
Volume 14
Issue 9
Start page 653
End page 657
Total pages 5
Place of publication New York, NY, United States
Publisher Elsevier
Language eng
Abstract To assess the relationship between circulating leptin concentrations, metabolic parameters, and lifestyle factors such as alcohol intake, physical activity level, smoking habits, and reproductive history, a cohort of 359 women was drawn from a population-based study conducted in Victoria. Australia. The parameters measured included body mass index (BMI); waist and hip circumference; blood pressure; and fasting glucose, insulin, triacylglycerol, cholesterol, and leptin concentrations. In addition, a self- administered questionnaire was used to assess reproductive history, physical activity level, alcohol intake, and smoking habits. Our results demonstrated that BMI, body weight, waist circumference, and hip circumference were all strongly correlated with circulating leptin concentrations in this population (r > 0.56, P < 0.001 in all cases). Waist/hip ratio, triacylglycerols, insulin, glucose, and cholesterol were also associated with leptin (P < 0.05), but there was no association between leptin and age, height, or blood pressure. When these associations were adjusted for BMI, age, glucose, and waist circumference were significantly associated with leptin. The lifestyle factors examined did not help to explain the observed variation in leptin concentrations between individuals when results were adjusted for degree of adiposity and age.
Keyword Leptin
Lifestyle factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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