Astaxanthin: A potential therapeutic agent in cardiovascular disease

Fassett, Robert G. and Coombes, Jeff S. (2011) Astaxanthin: A potential therapeutic agent in cardiovascular disease. Marine Drugs, 9 3: 447-465. doi:10.3390/md9030447


Author Fassett, Robert G.
Coombes, Jeff S.
Title Astaxanthin: A potential therapeutic agent in cardiovascular disease
Journal name Marine Drugs   Check publisher's open access policy
ISSN 1660-3397
Publication date 2011-03-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/md9030447
Open Access Status DOI
Volume 9
Issue 3
Start page 447
End page 465
Total pages 19
Editor Kazuo Miyashita
Takashi Maoka
Place of publication Basel, Switzerland
Publisher MDPI AG
Collection year 2012
Language eng
Abstract Astaxanthin is a xanthophyll carotenoid present in microalgae, fungi, complex plants, seafood, flamingos and quail. It is an antioxidant with anti-inflammatory properties and as such has potential as a therapeutic agent in atherosclerotic cardiovascular disease. Synthetic forms of astaxanthin have been manufactured. The safety, bioavailability and effects of astaxanthin on oxidative stress and inflammation that have relevance to the pathophysiology of atherosclerotic cardiovascular disease, have been assessed in a small number of clinical studies. No adverse events have been reported and there is evidence of a reduction in biomarkers of oxidative stress and inflammation with astaxanthin administration. Experimental studies in several species using an ischaemia-reperfusion myocardial model demonstrated that astaxanthin protects the myocardium when administered both orally or intravenously prior to the induction of the ischaemic event. At this stage we do not know whether astaxanthin is of benefit when administered after a cardiovascular event and no clinical cardiovascular studies in humans have been completed and/or reported. Cardiovascular clinical trials are warranted based on the physicochemical and antioxidant properties, the safety profile and preliminary experimental cardiovascular studies of astaxanthin. © 2011 by the authors; licensee MDPI.
Keyword Antioxidants
Haematococcus pluvialis
Inflammation
Oxidative stress
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue "Marine Carotenoids"

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Created: Thu, 19 May 2011, 20:40:27 EST by Professor Robert Fassett on behalf of Royal Brisbane Clinical School