Airway microbiology and host defences in paediatric non-CF bronchiectasis

Grimwood, Keith (2011) Airway microbiology and host defences in paediatric non-CF bronchiectasis. Paediatric Respiratory Reviews, 12 2: 111-118. doi:10.1016/j.prrv.2010.10.009


Author Grimwood, Keith
Title Airway microbiology and host defences in paediatric non-CF bronchiectasis
Journal name Paediatric Respiratory Reviews   Check publisher's open access policy
ISSN 1526-0542
1526-0550
Publication date 2011-06-01
Sub-type Article (original research)
DOI 10.1016/j.prrv.2010.10.009
Open Access Status Not Open Access
Volume 12
Issue 2
Start page 111
End page 118
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Bronchiectasis in children without cystic fibrosis is most common in socioeconomically disadvantaged communities. Recurrent pneumonia in early childhood and defective pulmonary defences are important risk factors. These help establish a 'vicious cycle' of impaired mucociliary clearance, infection, airway inflammation and progressive lung injury. Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis and Pseudomonas aeruginosa are the main infecting pathogens. H. influenzae predominates across all ages, while P. aeruginosa is found in older children with advanced disease. It is uncertain whether viruses and upper airway commensal bacteria play an important aetiological role. Overall, the microbiological data are limited however and there are difficulties obtaining reliable respiratory specimens from young children. Bronchiectasis is a complex disorder resulting from susceptibility to pulmonary infection and poorly regulated respiratory innate and adaptive immunity. Airway inflammatory responses are excessive and persist, even once infection is cleared. Improved specimen collection, molecular techniques and biomarkers are needed to enhance management.
© 2010 Elsevier Ltd.
Keyword Bronchiectasis
Child
Bacteria
Innate immunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under Mini-Symposium: Non-CF Bronchiectasis. Available online 4 December 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 19 Apr 2011, 21:32:24 EST by Professor Keith Grimwood on behalf of Faculty Of Health Sciences