Verbal fluency deficits in multiple sclerosis

Henry, Julie D. and Beatty, William W. (2006) Verbal fluency deficits in multiple sclerosis. Neuropsychologia, 44 7: 1166-1174. doi:10.1016/j.neuropsychologia.2005.10.006

Author Henry, Julie D.
Beatty, William W.
Title Verbal fluency deficits in multiple sclerosis
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 0028-3932
Publication date 2006-01-01
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2005.10.006
Open Access Status Not yet assessed
Volume 44
Issue 7
Start page 1166
End page 1174
Total pages 9
Place of publication Oxford, U.K.
Publisher Pergamon-Elsevier Science
Language eng
Formatted abstract
A quantitative review of 35 studies with 3673 participants was conducted to estimate and compare the magnitude of deficits upon tests of phonemic and semantic fluency for participants with multiple sclerosis (MS) relative to healthy controls. Participants with MS were substantially but similarly impaired on tests of phonemic and semantic fluency. These deficits were larger than deficits on measures of verbal intelligence, confrontation naming and another widely used measure of executive functioning, the Wisconsin Card Sorting Test, but were of a comparable or smaller magnitude relative to deficits on the oral version of the Symbol Digit Modalities Test (SDMT). This is consistent with other research suggesting that measures of verbal fluency and the SDMT may be amongst the most sensitive neuropsychological measures to cognitive impairment in MS. Increased neurological disability and a chronic progressive (as opposed to a relapsing remitting) disease course were associated with larger deficits on tests of phonemic and semantic fluency. However, it is suggested that this latter finding is attributable to the distinct clinical features of chronic progressive and relapsing remitting sub-types. Thus, patients who follow a chronic progressive course tend to be older, have an increased duration of illness and experience greater neurological disability. Once these variables were controlled for, differences between the two sub-types were substantially attenuated.
Keyword Meta-analysis
Disease course
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 15 November 2005.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Psychology Publications
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Created: Tue, 19 Apr 2011, 01:43:49 EST by Lucy O'Brien on behalf of School of Psychology