A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

Goode, Ellen L., Chenevix-Trench, Georgia, Song, Honglin, Ramus, Susan J., Notaridou, Maria, Lawrenson, Kate, Widschwendter, Martin, Vierkant, Robert A., Larson, Melissa C., Kjaer, Susanne K., Birrer, Michael J., Berchuck, Andrew, Schildkraut, Joellen, Tomlinson, Ian, Kiemeney, Lambertus A., Cook, Linda S., Gronwald, Jacek, Garcia-Closas, Montserrat, Gore, Martin E., Campbell, Ian, Whittemore, Alice S., Sutphen, Rebecca, Phelan, Catherine, Anton-Culver, Hoda, Pearce, Celeste Leigh, Lambrechts, Diether, Rossing, Mary Anne, Chang-Claude, Jenny, Moysich, Kirsten B., Goodman, Marc T., Dork, Thilo, Nevanlinna, Heli, Ness, Roberta B., Rafnar, Thorunn, Hogdall, Claus, Hogdall, Estrid, Fridley, Brooke L., Cunningham, Julie M., Sieh, Weiva, McGuire, Valerie, Godwin, Andrew K., Cramer, Daniel W., Hernandez, Dena, Levine, Douglas, Lu, Karen, Iversen, Edwin S., Palmieri, Rachel T., Houlston, Richard, van Altena, Anne M., Aben, Katja K. H., Massuger, Leon F. A. G., Brooks-Wilson, Angela, Kelemen, Linda E., Le, Nhu D., Jakubowska, Anna, Lubinski, Jan, Medrek, Krzysztof, Stafford, Anne, Easton, Douglas F., Tyrer, Jonathan, Bolton, Kelly L., Harrington, Patricia, Eccles, Diana, Chen, Ann, Molina, Ashley N., Davila, Barbara N., Arango, Hector, Tsai, Ya-Yu, Chen, Zhihua, Risch, Harvey A., McLaughlin, John, Narod, Steven A., Ziogas, Argyrios, Brewster, Wendy, Gentry-Maharaj, Aleksandra, Menon, Usha, Wu, Anna H., Stram, Daniel O., Pike, Malcolm C., The Wellcome Trust Case-Control Consortium, Beesley, Jonathan, Webb, Penelope M., The Australian Cancer Study (Ovarian Cancer), The Australian Ovarian Cancer Study Group, Chen, Xiaoqing, Ekici, Arif B., Thiel, Falk C., Beckmann, Matthias W., Yang, Hannah, Wentzensen, Nicolas, Lissowska, Jolanta, Fasching, Peter A., Despierre, Evelyn, Amant, Frederic, Vergote, Ignace, Doherty, Jennifer, Hein, Rebecca, Wang-Gohrke, Shan, Lurie, Galina, Carney, Michael E., Thompson, Pamela J., Runnebaum, Ingo, Hillemanns, Peter, Durst, Matthias, Antonenkova, Natalia, Bogdanova, Natalia, Leminen, Arto, Butzow, Ralf, Heikkinen, Tuomas, Stefansson, Kari, Sulem, Patrick, Besenbacher, Soren, Sellers, Thomas A., Gayther, Simon A., Pharoah, Paul D. P. and The Ovarian Cancer Association Consortium (OCAC) (2010) A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nature Genetics, 42 10: 874-879. doi:10.1038/ng.668

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Author Goode, Ellen L.
Chenevix-Trench, Georgia
Song, Honglin
Ramus, Susan J.
Notaridou, Maria
Lawrenson, Kate
Widschwendter, Martin
Vierkant, Robert A.
Larson, Melissa C.
Kjaer, Susanne K.
Birrer, Michael J.
Berchuck, Andrew
Schildkraut, Joellen
Tomlinson, Ian
Kiemeney, Lambertus A.
Cook, Linda S.
Gronwald, Jacek
Garcia-Closas, Montserrat
Gore, Martin E.
Campbell, Ian
Whittemore, Alice S.
Sutphen, Rebecca
Phelan, Catherine
Anton-Culver, Hoda
Pearce, Celeste Leigh
Lambrechts, Diether
Rossing, Mary Anne
Chang-Claude, Jenny
Moysich, Kirsten B.
Goodman, Marc T.
Dork, Thilo
Nevanlinna, Heli
Ness, Roberta B.
Rafnar, Thorunn
Hogdall, Claus
Hogdall, Estrid
Fridley, Brooke L.
Cunningham, Julie M.
Sieh, Weiva
McGuire, Valerie
Godwin, Andrew K.
Cramer, Daniel W.
Hernandez, Dena
Levine, Douglas
Lu, Karen
Iversen, Edwin S.
Palmieri, Rachel T.
Houlston, Richard
van Altena, Anne M.
Aben, Katja K. H.
Massuger, Leon F. A. G.
Brooks-Wilson, Angela
Kelemen, Linda E.
Le, Nhu D.
Jakubowska, Anna
Lubinski, Jan
Medrek, Krzysztof
Stafford, Anne
Easton, Douglas F.
Tyrer, Jonathan
Bolton, Kelly L.
Harrington, Patricia
Eccles, Diana
Chen, Ann
Molina, Ashley N.
Davila, Barbara N.
Arango, Hector
Tsai, Ya-Yu
Chen, Zhihua
Risch, Harvey A.
McLaughlin, John
Narod, Steven A.
Ziogas, Argyrios
Brewster, Wendy
Gentry-Maharaj, Aleksandra
Menon, Usha
Wu, Anna H.
Stram, Daniel O.
Pike, Malcolm C.
The Wellcome Trust Case-Control Consortium
Beesley, Jonathan
Webb, Penelope M.
The Australian Cancer Study (Ovarian Cancer)
The Australian Ovarian Cancer Study Group
Chen, Xiaoqing
Ekici, Arif B.
Thiel, Falk C.
Beckmann, Matthias W.
Yang, Hannah
Wentzensen, Nicolas
Lissowska, Jolanta
Fasching, Peter A.
Despierre, Evelyn
Amant, Frederic
Vergote, Ignace
Doherty, Jennifer
Hein, Rebecca
Wang-Gohrke, Shan
Lurie, Galina
Carney, Michael E.
Thompson, Pamela J.
Runnebaum, Ingo
Hillemanns, Peter
Durst, Matthias
Antonenkova, Natalia
Bogdanova, Natalia
Leminen, Arto
Butzow, Ralf
Heikkinen, Tuomas
Stefansson, Kari
Sulem, Patrick
Besenbacher, Soren
Sellers, Thomas A.
Gayther, Simon A.
Pharoah, Paul D. P.
The Ovarian Cancer Association Consortium (OCAC)
Title A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2010-10-01
Sub-type Article (original research)
DOI 10.1038/ng.668
Open Access Status Not yet assessed
Volume 42
Issue 10
Start page 874
End page 879
Total pages 6
Place of publication New York, U.S.A.
Publisher Nature Publishing Group
Language eng
Formatted abstract
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian cancer (cases) and 2,354 controls, with follow up of 21,955 SNPs in 4,162 cases and 4,810 controls, leading to the identification of a confirmed susceptibility locus at 9p22 (in BNC2). Here, we report on nine additional candidate loci (defined as having P 10 -4) identified after stratifying cases by histology, which we genotyped in an additional 4,353 cases and 6,021 controls. We confirmed two new susceptibility loci with P -5 × 10 -8 (8q24, P = 8.0 × 10 -15 and 2q31, P = 3.8 × 10 -14) and identified two additional loci that approached genome-wide significance (3q25, P = 7.1 × 10 -8 and 17q21, P = 1.4 × 10 -7). The associations of these loci with serous ovarian cancer were generally stronger than with other cancer subtypes. Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development.
© 2010 Nature America, Inc. All rights reserved.
Keyword Colorectal-cancer
Poly(adp-ribose) polymerase
Epithelial-cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sat, 09 Apr 2011, 03:26:56 EST by Debbie Banks on behalf of School of Medicine