Common variants at 19p13 are associated with susceptibility to ovarian cancer

Bolton, Kelly L., Tyrer, Jonathan, Song, Honglin, Ramus, Susan J., Notaridou, Maria, Jones, Chris, Sher, Tanya, Gentry-Maharaj, Aleksandra, Wozniak, Eva, Tsai, Ya-Yu, Weidhaas, Joanne, Paik, Daniel, Van Den Berg, David J., Stram, Daniel O., Pearce, Celeste Leigh, Wu, Anna H., Brewster, Wendy, Anton-Culver, Hoda, Ziogas, Argyrios, Narod, Steven A., Levine, Douglas A., Kaye, Stanley B., Brown, Robert, Paul, Jim, Flanagan, James, Sieh, Weiva, McGuire, Valerie, Whittemore, Alice S., Campbell, Ian, Gore, Martin E., Lissowska, Jolanta, Yang, Hanna P., Medrek, Krzysztof, Gronwald, Jacek, Lubinski, Jan, Jakubowska, Anna, Le, Nhu D., Cook, Linda S., Kelemen, Linda E., Brook-Wilson, Angela, Massuger, Leon F. A.G., Kiemeney, Lambertus A., Aben, Katja K. H., van Altena, Anne M., Houlston, Richard, Tomlinson, Ian, Palmieri, Rachel T., Moorman, Patricia G., Schildkraut, Joellen, Iversen, Edwin S., Phelan, Catherine, Vierkant, Robert A., Cunningham, Julie M., Goode, Ellen L., Fridley, Brooke L., Kruger-Kjaer, Susan, Blaeker, Jan, Hogdall, Estrid, Hogdall, Claus, Gross, Jenny, Karlan, Beth Y., Ness, Roberta B., Edwards, Robert P., Odunsi, Kunle, Moyisch, Kirsten B., Baker, Julie A., Modugno, Francesmary, Heikkinenen, Tuomas, Butzow, Ralf, Nevanlinna, Heli, Leminen, Arto, Bogdanova, Natalia, Antonenkova, Natalia, Doerk, Thilo, Hillemanns, Peter, Durst, Matthias, Runnebaum, Ingo, Thompson, Pamela J., Carney, Michael E., Goodman, Marc T., Lurie, Galina, Wang-Gohrke, Shan, Hein, Rebecca, Chang-Claude, Jenny, Rossing, Mary Anne, Cushing-Haugen, Kara L., Doherty, Jennifer, Chen, Chu, Rafnar, Thorunn, Besenbacher, Soren, Sulem, Patrick, Stefansson, Kari, Birrer, Michael J., Terry, Kathryn L., Hernandez, Dena, Cramer, Daniel W., Vergote, Ignace, Amant, Frederic, Lambrechts, Diether, Despierre, Evelyn, Fasching, Peter A., Beckmann, Matthias W., Thiel, Falk C., Ekici, Arif B., Chen, Xiaoqing, The Australian Ovarian Cancer Study Group, The Australian Cancer Study (Ovarian Cancer), on behalf of the Ovarian Cancer Association Consortium, Johnatty, Sharon E., Webb, Penelope M., Beesley, Jonathan, Chanock, Stephen, Garcia-Closas, Montserrat, Sellers, Tom, Easton, Douglas F., Berchuck, Andrew, Chenevix-Trench, Georgia, Pharoah, Paul D. P. and Gayther, Simon A. (2010) Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nature Genetics, 42 10: 880-884. doi:10.1038/ng.666

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Author Bolton, Kelly L.
Tyrer, Jonathan
Song, Honglin
Ramus, Susan J.
Notaridou, Maria
Jones, Chris
Sher, Tanya
Gentry-Maharaj, Aleksandra
Wozniak, Eva
Tsai, Ya-Yu
Weidhaas, Joanne
Paik, Daniel
Van Den Berg, David J.
Stram, Daniel O.
Pearce, Celeste Leigh
Wu, Anna H.
Brewster, Wendy
Anton-Culver, Hoda
Ziogas, Argyrios
Narod, Steven A.
Levine, Douglas A.
Kaye, Stanley B.
Brown, Robert
Paul, Jim
Flanagan, James
Sieh, Weiva
McGuire, Valerie
Whittemore, Alice S.
Campbell, Ian
Gore, Martin E.
Lissowska, Jolanta
Yang, Hanna P.
Medrek, Krzysztof
Gronwald, Jacek
Lubinski, Jan
Jakubowska, Anna
Le, Nhu D.
Cook, Linda S.
Kelemen, Linda E.
Brook-Wilson, Angela
Massuger, Leon F. A.G.
Kiemeney, Lambertus A.
Aben, Katja K. H.
van Altena, Anne M.
Houlston, Richard
Tomlinson, Ian
Palmieri, Rachel T.
Moorman, Patricia G.
Schildkraut, Joellen
Iversen, Edwin S.
Phelan, Catherine
Vierkant, Robert A.
Cunningham, Julie M.
Goode, Ellen L.
Fridley, Brooke L.
Kruger-Kjaer, Susan
Blaeker, Jan
Hogdall, Estrid
Hogdall, Claus
Gross, Jenny
Karlan, Beth Y.
Ness, Roberta B.
Edwards, Robert P.
Odunsi, Kunle
Moyisch, Kirsten B.
Baker, Julie A.
Modugno, Francesmary
Heikkinenen, Tuomas
Butzow, Ralf
Nevanlinna, Heli
Leminen, Arto
Bogdanova, Natalia
Antonenkova, Natalia
Doerk, Thilo
Hillemanns, Peter
Durst, Matthias
Runnebaum, Ingo
Thompson, Pamela J.
Carney, Michael E.
Goodman, Marc T.
Lurie, Galina
Wang-Gohrke, Shan
Hein, Rebecca
Chang-Claude, Jenny
Rossing, Mary Anne
Cushing-Haugen, Kara L.
Doherty, Jennifer
Chen, Chu
Rafnar, Thorunn
Besenbacher, Soren
Sulem, Patrick
Stefansson, Kari
Birrer, Michael J.
Terry, Kathryn L.
Hernandez, Dena
Cramer, Daniel W.
Vergote, Ignace
Amant, Frederic
Lambrechts, Diether
Despierre, Evelyn
Fasching, Peter A.
Beckmann, Matthias W.
Thiel, Falk C.
Ekici, Arif B.
Chen, Xiaoqing
The Australian Ovarian Cancer Study Group
The Australian Cancer Study (Ovarian Cancer)
on behalf of the Ovarian Cancer Association Consortium
Johnatty, Sharon E.
Webb, Penelope M.
Beesley, Jonathan
Chanock, Stephen
Garcia-Closas, Montserrat
Sellers, Tom
Easton, Douglas F.
Berchuck, Andrew
Chenevix-Trench, Georgia
Pharoah, Paul D. P.
Gayther, Simon A.
Title Common variants at 19p13 are associated with susceptibility to ovarian cancer
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2010-10-01
Sub-type Article (original research)
DOI 10.1038/ng.666
Volume 42
Issue 10
Start page 880
End page 884
Total pages 5
Place of publication New York, U.S.A.
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10-4 and P = 6×10-4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10-9 and P = 4×10-11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
© 2010 Nature America, Inc. All rights reserved.
Keyword Genome-wide Association
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 149 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 158 times in Scopus Article | Citations
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