Electrophysiological studies of malaria parasite-infected erythrocytes: Current status

Staines, Henry M., Alkhalil, Abdulnaser, Allen, Richard J., De Jonge, Hugo R., Derbyshire, Elvira, Egee, Stephane, Ginsburg, Hagai, Hill, David A., Huber, Stephan M., Kirk, Kiaran, Lang, Florian, Lisk, Godfrey, Oteng, Eugene, Pillai, Ajay D., Rayavara, Kempaiah, Rouhani, Sherin, Saliba, Kevin J., Shen, Crystal, Solomon, Tsione, Thomas, Serge L. Y., Verloo, Patrick and Desai, Sanjay A. (2007) Electrophysiological studies of malaria parasite-infected erythrocytes: Current status. International Journal of Parasitology, 37 5: 475-482. doi:10.1016/j.ijpara.2006.12.013


Author Staines, Henry M.
Alkhalil, Abdulnaser
Allen, Richard J.
De Jonge, Hugo R.
Derbyshire, Elvira
Egee, Stephane
Ginsburg, Hagai
Hill, David A.
Huber, Stephan M.
Kirk, Kiaran
Lang, Florian
Lisk, Godfrey
Oteng, Eugene
Pillai, Ajay D.
Rayavara, Kempaiah
Rouhani, Sherin
Saliba, Kevin J.
Shen, Crystal
Solomon, Tsione
Thomas, Serge L. Y.
Verloo, Patrick
Desai, Sanjay A.
Title Electrophysiological studies of malaria parasite-infected erythrocytes: Current status
Journal name International Journal of Parasitology   Check publisher's open access policy
ISSN 0020-7519
1879-0135
Publication date 2007-04-01
Sub-type Article (original research)
DOI 10.1016/j.ijpara.2006.12.013
Volume 37
Issue 5
Start page 475
End page 482
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding. © 2007 Australian Society for Parasitology Inc.
Keyword Ion channels
New permeability pathways
Oxidation
Patch-clamp
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Published under Current Opinion

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Fri, 08 Apr 2011, 00:25:58 EST by Susan Allen on behalf of Institute for Molecular Bioscience