Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells

McAllister, Sean D., Chan, Calvin, Taft, Ryan J., Luu, Tri, Abood, Mary E., Moore, Dan H., Aldape, Ken and Yount, Garret (2005) Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. Journal of Neuro-Oncology, 74 1: 31-40. doi:10.1007/s11060-004-5950-2


Author McAllister, Sean D.
Chan, Calvin
Taft, Ryan J.
Luu, Tri
Abood, Mary E.
Moore, Dan H.
Aldape, Ken
Yount, Garret
Title Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
Journal name Journal of Neuro-Oncology   Check publisher's open access policy
ISSN 0167-594X
1573-7373
Publication date 2005-08-01
Sub-type Article (original research)
DOI 10.1007/s11060-004-5950-2
Volume 74
Issue 1
Start page 31
End page 40
Total pages 10
Place of publication Secaucus, NJ, United States
Publisher Springer New York LLC
Language eng
Formatted abstract
Normal tissue toxicity limits the efficacy of current treatment modalities for glioblastoma multiforme (GBM). We evaluated the influence of cannabinoids on cell proliferation, death, and morphology of human GBM cell lines and in primary human glial cultures, the normal cells from which GBM tumors arise. The influence of a plant derived cannabinoid agonist, Δ9-tetrahydrocannabinol (Δ9-THC), and a potent synthetic cannabinoid agonist, WIN 55,212-2, were compared using time lapse microscopy. We discovered that Δ9-THC decreases cell proliferation and increases cell death of human GBM cells more rapidly than WIN 55,212-2. Δ9-THC was also more potent at inhibiting the proliferation of GBM cells compared to WIN 55,212-2. The effects of Δ9-THC and WIN 55,212-2 on the GBM cells were partially the result of cannabinoid receptor activation. The same concentration of Δ9-THC that significantly inhibits proliferation and increases death of human GBM cells has no significant impact on human primary glial cultures. Evidence of selective efficacy with WIN 55,212-2 was also observed but the selectivity was less profound, and the synthetic agonist produced a greater disruption of normal cell morphology compared to Δ9-THC.
Keyword Cannabinoid
Delta-9-tetrahydrocannabinol
Extracellular signal regulated kinases
Glioblastma multiforme
Time lapse microscopy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 40 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 04 Apr 2011, 23:31:22 EST