Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages

Labadie, Karine, Larcher, Thibaut, Joubert, Christophe, Mannioui, Abdelkrim, Delache, Benoit, Brochard, Patricia, Guigand, Lydie, Dubreil, Laurence, Lebon, Pierre, Verrier, Bernard, de Lamballerie, Xavier, Suhrbier, Andreas, Cherel, Yan, Le Grand, Roger and Roques, Pierre (2010) Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. Journal of Clinical Investigation, 120 3: 894-906. doi:10.1172/JCI40104

Author Labadie, Karine
Larcher, Thibaut
Joubert, Christophe
Mannioui, Abdelkrim
Delache, Benoit
Brochard, Patricia
Guigand, Lydie
Dubreil, Laurence
Lebon, Pierre
Verrier, Bernard
de Lamballerie, Xavier
Suhrbier, Andreas
Cherel, Yan
Le Grand, Roger
Roques, Pierre
Title Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
Journal name Journal of Clinical Investigation   Check publisher's open access policy
ISSN 0021-9738
Publication date 2010-03-01
Sub-type Article (original research)
DOI 10.1172/JCI40104
Open Access Status DOI
Volume 120
Issue 3
Start page 894
End page 906
Total pages 11
Editor Laurence A. Turka
Place of publication Ann Arbor, MI, U.S.A.
Publisher American Society for Clinical Investigation
Language eng
Formatted abstract
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean Islands and India has stressed the need to better understand the pathogenesis of this disease. Previous CHIKV disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. Herein, we describe what we believe to be a new model for CHIKV infection in adult, immunocompetent cynomolgus macaques. CHIKV infection in these animals recapitulated the viral, clinical, and pathological features observed in human disease. In the macaques, long-term CHIKV infection was observed in joints, muscles, lymphoid organs, and liver, which could explain the long-lasting CHIKV disease symptoms observed in humans. In addition, the study identified macrophages as the main cellular reservoirs during the late stages of CHIKV infection in vivo. This model of CHIKV physiopathology should allow the development of new therapeutic and/or prophylactic strategies.
Keyword Ross-River-virus
Equine encephalitis-virus
Human dendritic cells
E2 glycoprotein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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Created: Mon, 04 Apr 2011, 21:28:46 EST by Debbie Banks on behalf of !NON-HERDC