Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Elizabeth K Speliotes, Cristen J Willer, Sonja I Berndt, Keri L Monda, Gudmar Thorleifsson, Anne U Jackson, Hana Lango Allen, Cecilia M Lindgren, Jian'an Luan, Reedik Magi, Joshua C Randall, Sailaja Vedantam, Thomas W Winkler, Lu Qi, Tsegaselassie Workalemahu, Iris M Heid, Valgerdur Steinthorsdottir, Heather M Stringham, Michael N Weedon, Eleanor Wheeler, Andrew R Wood, Teresa Ferreira, Robert J Weyant, Ayellet V Segre, Karol Estrada, Liming Liang, James Nemesh, Ju-Hyun Park, Stefan Gustafsson, Tuomas O Kilpelainen, Jian Yang, Nabila Bouatia-Naji, Tonu Esko, Mary F Feitosa, Zoltan Kutalik, Massimo Mangino, Soumya Raychaudhuri, Andre Scherag, Albert Vernon Smith, Ryan Welch, Jing Hua Zhao, Katja K Aben, Devin M Absher, Najaf Amin, Anna L Dixon, Eva Fisher, Nicole L Glazer, Michael E Goddard, Nancy L Heard-Costa, Volker Hoesel, Jouke-Jan Hottenga, Asa Johansson, Toby Johnson, Shamika Ketkar, Claudia Lamina, Shengxu Li, Miriam F Moffatt, Richard h Myers, Narisu Narisu, John R B Perry, Marjolein J Peters, Michael Preuss, Samuli Ripatti, Fernando Rivadeneira, Camilla Sandholt, Laura J Scott, Nicholas J Timpson, Jonathan P Tyrer, Sophie van Wingerden, Richard M Watanabe, Charles C White, Fredrik Wiklund, Christina Barlassina, Daniel I Chasman, Matthew N Cooper, John-Olov Jansson, Robert W Lawrence, Niina Pellikka, Inga Prokopenko, Jianxin Shi, Elisabeth Thiering, Helene Alavere, Maria T S Alibrandi, Peter Almgren, Alice M Arnold, Thor Aspelund, Larry D Atwood, Beverley Balkau, Anthony J Balmforth, Amanda J Bennett, Yoav Ben-Shlomo, Richard N Bergman, Sven Bergmann, Heike Biebermann, Alexandra I F Blakemore, Tanja Boes, Lori L Bonnycastle, Stefan R Bornstein, Morris J Brown, Thomas A Buchanan, Fabio Busonero, Harry Campbell, Francesco P Cappuccio, Christine Cavalcanti-Proenca, Yii-Der Ida Chen, Chih-Mei Chen, Peter S Chines, Robert Clarke, Lachlan Coin, John Connell, Ian N M Day, Martin den Heijer, Jubao Duan, Shah Ebrahim, Paul Elliott, Roberto Elosua, Gudny Eiriksdottir, Michael R Erdos, Johan G Eriksson, Maurizio F Facheris, Stephan B Felix, Pamela Fischer-Posovszky, Aaron R Folsom, Nele Friedrich, Nelson B Freimer, Mao Fu, Stefan Gaget, Pablo V Gejman, Eco J C Geus, Christian Gieger, Anette P Gjesing, Anuj Goel, Philippe Goyette, Harald Grallert, Jurgen Grassler, Danielle M Greenawalt, Christopher J Groves, Vilmundur Gudnason, Candace Guiducci, Anna-Liisa Hartikainen, Neelam Hassanali, Alistair S Hall, Aki S Havulinna, Caroline Hayward, Andrew C Heath, Christian Hengstenberg, Andrew A Hicks, Anke Hinney, Albert Hofman, Georg Homuth, Jennie Hui, Wilmar Igl, Carlos Iribarren, Bo Isomaa, Kevin B Jacobs, Ivonne Jarick, Elizabeth Jewell, Ulrich John, Torben Jorgensen, Pekka Jousilahti, Antti Jula, Marika Kaakinen, Eero Kajantie, Lee M Kaplan, Sekar Kathiresan, Johannes Kettunen, Leena Kinnunen, Joshua W Knowles, Ivana Kolcic, Inke R Konig, Seppo Koskinen, Peter Kovacs, Johanna Kuusisto, Peter Kraft, Kirsti Kvaloy, Jaana Laitinen, Olivier Lantieri, Chiara Lanzani, Lenore J Launer, Cecile Lecoeur, Terho Lehtimaki, Guillaume Lettre, Jianjun Liu, Marja-Liisa Lokki, Mattias Lorentzon, Robert N Luben, Barbara Ludwig, The MAGIC (Meta-Analyses of Glucose and Insulin-Related Traits Consortium) investigators, Paolo Manunta, Diana Marek, Michel Marre, Martin, Nicholas G., Wendy L McArdle, Anne McCarthy, Barbara McKnight, Thomas Meitinger, Olle Melander, David Meyre, Kristian Midthjell, Montgomery, Grant W., Mario A Morken, Andrew P Morris, Rosanda Mulic, Julius S Ngwa, Mari Nelis, Matt J Neville, Nyholt, Dale R., Christopher J O'Donnell, Stephen O'Rahilly, Ken K Ong, Ben Oostra, Guillaume Pare, Alex N Parker, Markus Perola, Irene Pichler, Kirsi H Pietilainen, Carl G P Platou, Ozren Polasek, Anneli Pouta, Suzanne Rafelt, Olli Raitakari, Nigel W Rayner, Martin Ridderstrale, Winfried Rief, Aimo Ruokonen, Neil R Robertson, Peter Rzehak, Veikko Salomaa, Alan R Sanders, Manjinder S Sandhu, Serena Sanna, Jouko Saramies, Markku J Savolainen, Susann Scherag, Sabine Schipf, Stefan Schreiber, Heribert Schunkeret, Kaisa Silander, Juha Sinisalo, David S Siscovick, Jan H Smit, Nicole Soranzo, Ulla Sovio, Jonathan Sephens, Ida Surakka, Amy J Swift, Mari-Liis Tammesoo, Jean-Claude Tardif, Maris Teder-Laving, Tanya M Teslovich, John R Thompson, Brian Thomson, Anke Tonjes, Tiinamaija Tuomi, Joyce B J van Meurs, Gert-Jan van Ommen, Vincent Vatin, Jorma Viikari, Sophie Visvikis-Siest, Veronique Vitart, Carla I G Vogel, Benjamin F Voight, Lindsay L Waite, Henri Wallaschofski, G Bragi Walters, Elisabeth Widen, Susanna Wiegand, Sarah H Wild, Gonneke Willemsen, Daniel R Witte, Jacqueline C Witteman, Jianfeng Xu, Qunyuan Zhang, Lina Zgaga, Andreas Ziegler, Paavo Zitting, John P Beilby, I Sadaf Farooqi, Johannes Hebebrand, Heikki V Huikuri, Alan L James, Mika Kahonen, Douglas F Levinson, Fabio Macciardi, Markku S Nieminen, Claes Ohlsson, Lyle J Palmer, Paul M Ridker, Michael Stumvoll, Jacques S Beckmann, Heiner Boeing, Eric Boerwinkle, Dorret I Boomsma, Mark J Caulfield, Stephen J Chanock, Francis S Collins, L Adreienne Cupples, George Davey Smith, Jeanette Erdmann, Philippe Froguel, Henrik Gronberg, Ulf Gyllensten, Per Hall, Torben Hansen, Tamara B Harris, Andrew T Hattersley, Richard B Hayes, Joachim Heinrich, Frank B Hu, Kristian Hveem, Thomas Illig, Marjo-Riitta Jarvelin, Jaakko Kaprio, Fredrik Karpe, Kay-Tee Khaw, Lambertus A Kiemeney, Heiko Krude, Markku Laakso, Debbie A Lawlor, Andres Metspalu, Patricia B Munroe, Willem H Ouwehand, Oluf Pedersen, Brenda W Penninx, Annette Peters, Peter P Pramstaller, Thomas Quertermous, Thomas Reinehr, Aila Rissanen, Igor Rudan, Nilesh J Samani, Peter E H Schwarz, Alan R Shuldiner, Timothy D Spector, Jaakko Tuomilehto, Manuela Uda, Andre Uitterlinden, Timo T Valle, Martin Wabitsch, Gerard Waeber, Nicholas J Wareham, Hugh Watkins, James F Wilson, Alan F Wright, M Carola Zillikens, Nilanjan Chatterjee, Steven A McCarroll, Shaun Purcell, Eric E Schadt, Visscher, Peter M., Themistocles L Assimes, Ingrid B Borecki, Panos Deloukas, Caroline S Fox, Leif C Groop, Talin Haritunians, David J Hunter, Robert C Kaplan, Karen L Mohlke, Jeffrey R O'Connell, Leena Peltonen, David Schlessinger, David P Strachan, Cornelia M van Duijn, H-Erich Wichmann, Timothy M Frayling, Unnur Thorsteinsdottir, Goncalo R Abecasis, Ines Barroso, Michael Boehnke, Kari Stefansson, Kari E North, Mark I McCarthy, Joel N Hirschhorn, Erik Ingelsson and Ruth J F Loos (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, 42 11: 937-948. doi:10.1038/ng.686

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Author Elizabeth K Speliotes
Cristen J Willer
Sonja I Berndt
Keri L Monda
Gudmar Thorleifsson
Anne U Jackson
Hana Lango Allen
Cecilia M Lindgren
Jian'an Luan
Reedik Magi
Joshua C Randall
Sailaja Vedantam
Thomas W Winkler
Lu Qi
Tsegaselassie Workalemahu
Iris M Heid
Valgerdur Steinthorsdottir
Heather M Stringham
Michael N Weedon
Eleanor Wheeler
Andrew R Wood
Teresa Ferreira
Robert J Weyant
Ayellet V Segre
Karol Estrada
Liming Liang
James Nemesh
Ju-Hyun Park
Stefan Gustafsson
Tuomas O Kilpelainen
Jian Yang
Nabila Bouatia-Naji
Tonu Esko
Mary F Feitosa
Zoltan Kutalik
Massimo Mangino
Soumya Raychaudhuri
Andre Scherag
Albert Vernon Smith
Ryan Welch
Jing Hua Zhao
Katja K Aben
Devin M Absher
Najaf Amin
Anna L Dixon
Eva Fisher
Nicole L Glazer
Michael E Goddard
Nancy L Heard-Costa
Volker Hoesel
Jouke-Jan Hottenga
Asa Johansson
Toby Johnson
Shamika Ketkar
Claudia Lamina
Shengxu Li
Miriam F Moffatt
Richard h Myers
Narisu Narisu
John R B Perry
Marjolein J Peters
Michael Preuss
Samuli Ripatti
Fernando Rivadeneira
Camilla Sandholt
Laura J Scott
Nicholas J Timpson
Jonathan P Tyrer
Sophie van Wingerden
Richard M Watanabe
Charles C White
Fredrik Wiklund
Christina Barlassina
Daniel I Chasman
Matthew N Cooper
John-Olov Jansson
Robert W Lawrence
Niina Pellikka
Inga Prokopenko
Jianxin Shi
Elisabeth Thiering
Helene Alavere
Maria T S Alibrandi
Peter Almgren
Alice M Arnold
Thor Aspelund
Larry D Atwood
Beverley Balkau
Anthony J Balmforth
Amanda J Bennett
Yoav Ben-Shlomo
Richard N Bergman
Sven Bergmann
Heike Biebermann
Alexandra I F Blakemore
Tanja Boes
Lori L Bonnycastle
Stefan R Bornstein
Morris J Brown
Thomas A Buchanan
Fabio Busonero
Harry Campbell
Francesco P Cappuccio
Christine Cavalcanti-Proenca
Yii-Der Ida Chen
Chih-Mei Chen
Peter S Chines
Robert Clarke
Lachlan Coin
John Connell
Ian N M Day
Martin den Heijer
Jubao Duan
Shah Ebrahim
Paul Elliott
Roberto Elosua
Gudny Eiriksdottir
Michael R Erdos
Johan G Eriksson
Maurizio F Facheris
Stephan B Felix
Pamela Fischer-Posovszky
Aaron R Folsom
Nele Friedrich
Nelson B Freimer
Mao Fu
Stefan Gaget
Pablo V Gejman
Eco J C Geus
Christian Gieger
Anette P Gjesing
Anuj Goel
Philippe Goyette
Harald Grallert
Jurgen Grassler
Danielle M Greenawalt
Christopher J Groves
Vilmundur Gudnason
Candace Guiducci
Anna-Liisa Hartikainen
Neelam Hassanali
Alistair S Hall
Aki S Havulinna
Caroline Hayward
Andrew C Heath
Christian Hengstenberg
Andrew A Hicks
Anke Hinney
Albert Hofman
Georg Homuth
Jennie Hui
Wilmar Igl
Carlos Iribarren
Bo Isomaa
Kevin B Jacobs
Ivonne Jarick
Elizabeth Jewell
Ulrich John
Torben Jorgensen
Pekka Jousilahti
Antti Jula
Marika Kaakinen
Eero Kajantie
Lee M Kaplan
Sekar Kathiresan
Johannes Kettunen
Leena Kinnunen
Joshua W Knowles
Ivana Kolcic
Inke R Konig
Seppo Koskinen
Peter Kovacs
Johanna Kuusisto
Peter Kraft
Kirsti Kvaloy
Jaana Laitinen
Olivier Lantieri
Chiara Lanzani
Lenore J Launer
Cecile Lecoeur
Terho Lehtimaki
Guillaume Lettre
Jianjun Liu
Marja-Liisa Lokki
Mattias Lorentzon
Robert N Luben
Barbara Ludwig
The MAGIC (Meta-Analyses of Glucose and Insulin-Related Traits Consortium) investigators
Paolo Manunta
Diana Marek
Michel Marre
Martin, Nicholas G.
Wendy L McArdle
Anne McCarthy
Barbara McKnight
Thomas Meitinger
Olle Melander
David Meyre
Kristian Midthjell
Montgomery, Grant W.
Mario A Morken
Andrew P Morris
Rosanda Mulic
Julius S Ngwa
Mari Nelis
Matt J Neville
Nyholt, Dale R.
Christopher J O'Donnell
Stephen O'Rahilly
Ken K Ong
Ben Oostra
Guillaume Pare
Alex N Parker
Markus Perola
Irene Pichler
Kirsi H Pietilainen
Carl G P Platou
Ozren Polasek
Anneli Pouta
Suzanne Rafelt
Olli Raitakari
Nigel W Rayner
Martin Ridderstrale
Winfried Rief
Aimo Ruokonen
Neil R Robertson
Peter Rzehak
Veikko Salomaa
Alan R Sanders
Manjinder S Sandhu
Serena Sanna
Jouko Saramies
Markku J Savolainen
Susann Scherag
Sabine Schipf
Stefan Schreiber
Heribert Schunkeret
Kaisa Silander
Juha Sinisalo
David S Siscovick
Jan H Smit
Nicole Soranzo
Ulla Sovio
Jonathan Sephens
Ida Surakka
Amy J Swift
Mari-Liis Tammesoo
Jean-Claude Tardif
Maris Teder-Laving
Tanya M Teslovich
John R Thompson
Brian Thomson
Anke Tonjes
Tiinamaija Tuomi
Joyce B J van Meurs
Gert-Jan van Ommen
Vincent Vatin
Jorma Viikari
Sophie Visvikis-Siest
Veronique Vitart
Carla I G Vogel
Benjamin F Voight
Lindsay L Waite
Henri Wallaschofski
G Bragi Walters
Elisabeth Widen
Susanna Wiegand
Sarah H Wild
Gonneke Willemsen
Daniel R Witte
Jacqueline C Witteman
Jianfeng Xu
Qunyuan Zhang
Lina Zgaga
Andreas Ziegler
Paavo Zitting
John P Beilby
I Sadaf Farooqi
Johannes Hebebrand
Heikki V Huikuri
Alan L James
Mika Kahonen
Douglas F Levinson
Fabio Macciardi
Markku S Nieminen
Claes Ohlsson
Lyle J Palmer
Paul M Ridker
Michael Stumvoll
Jacques S Beckmann
Heiner Boeing
Eric Boerwinkle
Dorret I Boomsma
Mark J Caulfield
Stephen J Chanock
Francis S Collins
L Adreienne Cupples
George Davey Smith
Jeanette Erdmann
Philippe Froguel
Henrik Gronberg
Ulf Gyllensten
Per Hall
Torben Hansen
Tamara B Harris
Andrew T Hattersley
Richard B Hayes
Joachim Heinrich
Frank B Hu
Kristian Hveem
Thomas Illig
Marjo-Riitta Jarvelin
Jaakko Kaprio
Fredrik Karpe
Kay-Tee Khaw
Lambertus A Kiemeney
Heiko Krude
Markku Laakso
Debbie A Lawlor
Andres Metspalu
Patricia B Munroe
Willem H Ouwehand
Oluf Pedersen
Brenda W Penninx
Annette Peters
Peter P Pramstaller
Thomas Quertermous
Thomas Reinehr
Aila Rissanen
Igor Rudan
Nilesh J Samani
Peter E H Schwarz
Alan R Shuldiner
Timothy D Spector
Jaakko Tuomilehto
Manuela Uda
Andre Uitterlinden
Timo T Valle
Martin Wabitsch
Gerard Waeber
Nicholas J Wareham
Hugh Watkins
James F Wilson
Alan F Wright
M Carola Zillikens
Nilanjan Chatterjee
Steven A McCarroll
Shaun Purcell
Eric E Schadt
Visscher, Peter M.
Themistocles L Assimes
Ingrid B Borecki
Panos Deloukas
Caroline S Fox
Leif C Groop
Talin Haritunians
David J Hunter
Robert C Kaplan
Karen L Mohlke
Jeffrey R O'Connell
Leena Peltonen
David Schlessinger
David P Strachan
Cornelia M van Duijn
H-Erich Wichmann
Timothy M Frayling
Unnur Thorsteinsdottir
Goncalo R Abecasis
Ines Barroso
Michael Boehnke
Kari Stefansson
Kari E North
Mark I McCarthy
Joel N Hirschhorn
Erik Ingelsson
Ruth J F Loos
Title Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2010-11-01
Year available 2010
Sub-type Article (original research)
DOI 10.1038/ng.686
Open Access Status Not yet assessed
Volume 42
Issue 11
Start page 937
End page 948
Total pages 12
Place of publication New York, NY, U.S.A.
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
Formatted abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
© 2010 Nature America, Inc. All rights reserved.
Keyword Genome-wide association
Gastric-inhibitory polypeptide
Melanocortin-4 receptor gene
Glucose-homeostasis
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 10404
241944
DP0770096
1192
97020
HE 1446/4-1
QLG1-CT-2000-01643
01AK803
KFO-152
FKZ 01GS0823
B27
G0000649
216-1080315-0302
Institutional Status UQ
Additional Notes These authors on behalf of Procardis Consortium: James F. Wilson, Alan F. Wright, M. Carola Zillikens, Nilanjan Chatterjee, Steven A. McCarroll, Shaun Purcell, Eric E. Schadt, Peter M. Visscher, Themistocles L. Assimes, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Leif C. Groop, Talin Haritunians, David J. Hunter, Robert C. Kaplan, Karen L. Mohlke, Jeffrey R. O’Connell, Leena Peltonen, David Schlessinger, David P. Strachan, Cornelia Mvan Duijn, H.-Erich Wichmann, Timothy M. Frayling, Unnur Thorsteinsdottir, Gonçalo R. Abecasis, Inês Barroso, Michael Boehnke, Kari Stefansson, Kari E. North, Mark I. McCarthy, Joel N. Hirschhorn, Erik Ingelsson & Ruth J. F. Loos.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 31 Mar 2011, 19:32:23 EST by Debbie Banks on behalf of Medicine - Royal Brisbane and Women's Hospital