Posttraumatic epilepsy models

Kharatishvili, I. and Pitkanen, A. (2009). Posttraumatic epilepsy models. In Philip A. Schwartzkroin (Ed.), Encyclopedia of Basic Epilepsy Research (pp. 1229-1238) Oxford (U.K.): Academy Press (Elsevier).

Author Kharatishvili, I.
Pitkanen, A.
Title of chapter Posttraumatic epilepsy models
Title of book Encyclopedia of Basic Epilepsy Research
Place of Publication Oxford (U.K.)
Publisher Academy Press (Elsevier)
Publication Year 2009
Sub-type Chapter in textbook
ISBN 9780123736888
Editor Philip A. Schwartzkroin
Volume number 3
Start page 1229
End page 1238
Total pages 10
Language eng
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Abstract Posttraumatic epilepsy is defined as a recurrent seizure disorder due to injury to the brain following head trauma. Multiple theories have been suggested to explain the mechanisms underlying this clinical condition, and these hypotheses are currently under investigation. Valid and reliable animal models are essential for mechanistic and therapeutic studies of posttraumatic epilepsy. Development and characterization of such models should be a continuous and reciprocal process between the experimental laboratory and the clinic. Several experimental models of posttraumatic epilepsy are currently in use that may facilitate discovery of molecular and pathophysiological alterations underlying the process of epileptogenesis. Once the mechanisms of posttraumatic epilepsy are elucidated, appropriate therapies can be designed that can prevent epilepsy after head trauma.

Document type: Book Chapter
Collection: Centre for Advanced Imaging Publications
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Created: Wed, 30 Mar 2011, 16:10:38 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging