The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12

Reed, Danielle R., Zhu, Gu, Breslin, Paul A. S., Duke, Fujiko F., Henders, Anjali K., Campbell, Megan J., Montgomery, Grant W., Medland, Sarah E., Martin, Nicholas G. and Wright, Margaret J. (2010) The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Human Molecular Genetics, 19 21: 4278-4285. doi:10.1093/hmg/ddq324

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Author Reed, Danielle R.
Zhu, Gu
Breslin, Paul A. S.
Duke, Fujiko F.
Henders, Anjali K.
Campbell, Megan J.
Montgomery, Grant W.
Medland, Sarah E.
Martin, Nicholas G.
Wright, Margaret J.
Title The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
1460-2083
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1093/hmg/ddq324
Open Access Status DOI
Volume 19
Issue 21
Start page 4278
End page 4285
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
The perceived taste intensities of quinine HCl, caffeine, sucrose octaacetate (SOA) and propylthiouracil (PROP) solutions were examined in 1457 twins and their siblings. Previous heritability modeling of these bitter stimuli indicated a common genetic factor for quinine, caffeine and SOA (22-28%), as well as separate specific genetic factors for PROP (72%) and quinine (15%). To identify the genes involved, we performed a genome-wide association study with the same sample as the modeling analysis, genotyped for approximately 610 000 single-nucleotide polymorphisms (SNPs). For caffeine and SOA, no SNP association reached a genome-wide statistical criterion. For PROP, the peak association was within TAS2R38 (rs713598, A49P, P = 1.6 × 10-104), which accounted for 45.9% of the trait variance. For quinine, the peak association was centered in a region that contains bitter receptor as well as salivary protein genes and explained 5.8% of the trait variance (TAS2R19, rs10772420, R299C, P = 1.8 × 10-15). We confirmed this association in a replication sample of twins of similar ancestry (P = 0.00001). The specific genetic factor for the perceived intensity of PROP was identified as the gene previously implicated in this trait (TAS2R38). For quinine, one or more bitter receptor or salivary proline-rich protein genes on chromosome 12 have alleles which affect its perception but tight linkage among very similar genes precludes the identification of a single causal genetic variant.

Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # ddq324

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Wed, 30 Mar 2011, 01:01:59 EST by Debbie Banks on behalf of Medicine - Royal Brisbane and Women's Hospital