Targeting and dissolution characteristics of bone forming and antibacterial drugs by harnessing the structure of microspherical shells from coral beach sand

Chou, Joshua, Ben-Nissan, Besim, Green, David W., Valenzuela, Stella M. and Kohan, Lawrence (2011) Targeting and dissolution characteristics of bone forming and antibacterial drugs by harnessing the structure of microspherical shells from coral beach sand. Advanced Engineering Materials, 13 1-2: 93-99. doi:10.1002/adem.201000208


Author Chou, Joshua
Ben-Nissan, Besim
Green, David W.
Valenzuela, Stella M.
Kohan, Lawrence
Title Targeting and dissolution characteristics of bone forming and antibacterial drugs by harnessing the structure of microspherical shells from coral beach sand
Journal name Advanced Engineering Materials   Check publisher's open access policy
ISSN 1438-1656
1527-2648
Publication date 2011-02-01
Year available 2010
Sub-type Article (original research)
DOI 10.1002/adem.201000208
Open Access Status Not yet assessed
Volume 13
Issue 1-2
Start page 93
End page 99
Total pages 7
Place of publication Weinheim, Germany
Publisher Wiley - VCH Verlag
Language eng
Formatted abstract
Pharmaceutical drugs for the treatment of metabolic bone diseases lead to a number of side effects due to the their uncontrollable dispersion throughout the body. Therefore, many groups directed their research to develop devices that are targeted to specific organs or tissues and release the encapsulated drug in a highly regulated way. The development of completely resorbable bone-filling biomaterials delivering drugs would offer a therapeutic approach of drug release and bone augmentation in a simple one-step process. The biomaterials selected needs custom designs, to control the quantity and the duration of drug release and at the same time inducing desirable host cell responses and preventing bacterial infection. Current synthetic biomaterials produced as drug delivery microspheres due to production difficulties contain not very well designed interconnected pores and fail to fill these pertinent requirements.

Turning directly to nature such as marine structures for inventive solutions can help to solve these problems due to their structure, chemistry and architecture and their unique designs.

We demonstrate -for the first time- the potential of unique coral shells with specific microspherical structure and highly organised interconnected intra-pore designs to offer a number of desired functions for targeted delivery of Bisphosphonate (BP) (paminodrate) and an antibiotic (Gentamicin) for bone regeneration, repair and preventive antibacterial slow drug delivery.
Keyword Antibacterial drugs
Beach sand
Coral shells
Microspherical structure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Article first published online: 2 NOV 2010. Published under Communications.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
ERA 2012 Admin Only
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 29 Mar 2011, 19:19:37 EST by Debbie Banks on behalf of Aust Institute for Bioengineering & Nanotechnology