TNF family members and malaria: Old observations, new insights and future directions

Randall, Louise M. and Engwerda, Christian R. (2010) TNF family members and malaria: Old observations, new insights and future directions. Experimental Parasitology, 126 3: 326-331. doi:10.1016/j.exppara.2010.04.016

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Author Randall, Louise M.
Engwerda, Christian R.
Title TNF family members and malaria: Old observations, new insights and future directions
Journal name Experimental Parasitology   Check publisher's open access policy
ISSN 0014-4894
1090-2449
Publication date 2010-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.exppara.2010.04.016
Volume 126
Issue 3
Start page 326
End page 331
Total pages 6
Editor John Horton
Place of publication Maryland Heights, MO, U.S.A.
Publisher Academic Press
Language eng
Formatted abstract
Tumor necrosis factor (TNF) has long been recognized to promote malaria parasite killing, but also to contribute to the development of severe malaria disease. The precise molecular mechanisms that influence these different outcomes in malaria patients are not well understood, but the virulence and drug-resistance phenotype of malaria parasites and the genetic background and age of patients are likely to be important determinants. In the past few years, important roles for other TNF family members in host immune responses to malaria parasites and the induction of disease pathology have been discovered. In this review, we will summarize these more recent findings and highlight major gaps in our current knowledge. We will also discuss future research strategies that may allow us to better understand the sometimes subtle and intricate effects of TNF family molecules during malaria infection.
Crown Copyright © 2010 Published by Elsevier Inc. All rights reserved.
Keyword Malaria
TNF
Plasmodium berghei ANKA
Plasmodium falciparum
Regulatory T cell
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Mon, 28 Mar 2011, 20:05:44 EST by Lisa Hennell on behalf of Medicine - Royal Brisbane and Women's Hospital