Genetic influences on cost-efficient organization of human cortical functional networks

Fornito, Alex, Zalesky, Andrew, Bassett, Danielle S., Meunier, David, Ellison-Wright, Ian, Yucel, Murat, Wood, Stephen J., Shaw, Karen, O'Connor, Jennifer, Nertney, Deborah, Mowry, Bryan J., Pantelis, Christos and Bullmore, Edward T. (2011) Genetic influences on cost-efficient organization of human cortical functional networks. Journal of Neuroscience, 31 9: 3261-3270. doi:10.1523/JNEUROSCI.4858-10.2011

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Author Fornito, Alex
Zalesky, Andrew
Bassett, Danielle S.
Meunier, David
Ellison-Wright, Ian
Yucel, Murat
Wood, Stephen J.
Shaw, Karen
O'Connor, Jennifer
Nertney, Deborah
Mowry, Bryan J.
Pantelis, Christos
Bullmore, Edward T.
Title Genetic influences on cost-efficient organization of human cortical functional networks
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2011-03-01
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4858-10.2011
Open Access Status File (Publisher version)
Volume 31
Issue 9
Start page 3261
End page 3270
Total pages 10
Place of publication Washington DC, United States
Publisher Society for Neuroscience
Language eng
Subject 2800 Neuroscience
Abstract The human cerebral cortex is a complex network of functionally specialized regions interconnected by axonal fibers, but the organizational principles underlying cortical connectivity remain unknown. Here, we report evidence that one such principle for functional cortical networks involves finding a balance between maximizing communication efficiency and minimizing connection cost, referred to as optimization of network cost-efficiency. We measured spontaneous fluctuations of the blood oxygenation level-dependent signal using functional magnetic resonance imaging in healthy monozygotic (16 pairs) and dizygotic (13 pairs) twins and characterized cost-efficient properties of brain network functional connectivity between 1041 distinct cortical regions. At the global network level, 60% of the interindividual variance in cost-efficiency of cortical functional networks was attributable to additive genetic effects. Regionally, significant genetic effects were observed throughout the cortex in a largely bilateral pattern, including bilateral posterior cingulate and medial prefrontal cortices, dorsolateral prefrontal and superior parietal cortices, and lateral temporal and inferomedial occipital regions. Genetic effects were stronger for cost-efficiency than for other metrics considered, and were more clearly significant in functional networks operating in the 0.09–0.18 Hz frequency interval than at higher or lower frequencies. These findings are consistent with the hypothesis that brain networks evolved to satisfy competitive selection criteria of maximizing efficiency and minimizing cost, and that optimization of network cost-efficiency represents an important principle for the brain's functional organization.
Keyword Graph-theoretical analysis
Surface-based analysis
Small-world networks
Human brain
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
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Citation counts: TR Web of Science Citation Count  Cited 153 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 27 Mar 2011, 10:06:10 EST