Recent advances in vaccine research against schistosomiasis in Brazil

Oliveira, Sergio C., Fonseca, Cristina T., Cardoso, Fernanda C., Farias, Leonardo P. and Leite, Luciana C. C. (2008) Recent advances in vaccine research against schistosomiasis in Brazil. Acta Tropica, 108 2-3: 256-262. doi:10.1016/j.actatropica.2008.05.023

Author Oliveira, Sergio C.
Fonseca, Cristina T.
Cardoso, Fernanda C.
Farias, Leonardo P.
Leite, Luciana C. C.
Title Recent advances in vaccine research against schistosomiasis in Brazil
Journal name Acta Tropica   Check publisher's open access policy
ISSN 0001-706X
Publication date 2008-11-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.actatropica.2008.05.023
Open Access Status DOI
Volume 108
Issue 2-3
Start page 256
End page 262
Total pages 7
Editor Robert Bergquist
Rodrigo Correa-Oliveira
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Schistosomiasis continues to be a significant public health problem in tropical countries such as Brazil. Even though drug treatment in endemic areas has been shown to be efficient for controlling morbidity, it does not reduce prevalence due to constant reinfections. Therefore, a long-term disease control strategy is needed combining mass chemotherapy with a protective vaccine. Although the field of vaccine development has experienced more failures than successes, encouraging results have been obtained in recent years using defined recombinant derived Schistosoma mansoni antigens. This article primarily reviews the progress in the development of a vaccine against S. mansoni in Brazil. We discuss here different forms of vaccine tested in Brazil in pre-clinical trials and immunologic studies performed with patients in endemic areas of schistosomiasis. Lastly, we reviewed the S. mansoni genomic projects developed in the country and the recent advances in the identification of new molecules with potential as vaccine targets.
Keyword Schistosoma mansoni
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Journal issue: Schisto Research Brazil, November-December 2008

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 22 Mar 2011, 22:20:20 EST by Susan Allen on behalf of Institute for Molecular Bioscience