Cutaneous metabolism and active transport in transdermal drug delivery

Dancik, Yuri, Thompson, Camilla, Krishnan, Gayathri and Roberts, Michael S. (2010). Cutaneous metabolism and active transport in transdermal drug delivery. In Nancy A. Monteiro-Riviere, A. Wallace Hayes, John A. Thomas and Donald E. Gardner (Ed.), Toxicology of the skin (pp. 69-82) New York , NY, U.S.A.: Informa Healthcare USA.

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Name Description MIMEType Size Downloads
Author Dancik, Yuri
Thompson, Camilla
Krishnan, Gayathri
Roberts, Michael S.
Title of chapter Cutaneous metabolism and active transport in transdermal drug delivery
Title of book Toxicology of the skin
Place of Publication New York , NY, U.S.A.
Publisher Informa Healthcare USA
Publication Year 2010
Sub-type Research book chapter (original research)
Open Access Status
Series Target Organ Toxicology
ISBN 9781420079180
ISSN 1073-0842
Editor Nancy A. Monteiro-Riviere
A. Wallace Hayes
John A. Thomas
Donald E. Gardner
Volume number 29
Chapter number 7
Start page 69
End page 82
Total pages 14
Total chapters 27
Collection year 2011
Language eng
Formatted Abstract/Summary
As the largest organ of the human body, the skin provides an exceptional heterogeneous interface to protect the internal organs from various physical and chemical environmental insults by functioning as a physical, metabolic, and anti-UV barrier. It is well documented in the percutaneous penetration literature that the tightly packed lipid bilayer of the stratum corneum is efficacious in preventing exogenous compounds from entering the body. Most of the work done on the skin barrier focuses on the stratum corneum's physical barrier property. However, the skin should not only be thought of as an inert barrier. It is also a chemically active barrier, with enzymes located in the viable epidermis as well as in the extracellular spaces of the stratum corneum and the dermis, in which the primary sites of metabolism are the skin appendages. Cutaneous transport proteins expressed in skin constitute a second part of the chemical barrier function of the skin. Keratinocytes are the sites of expression of these proteins, which can act as substrates for a variety of topically applied compounds. In this brief review we focus on the possible therapeutic and adverse effects that cutaneous enzymes and transporters have on drug penetration into the skin. We also focus on the predictive role of mathematical models in understanding cutaneous biotransformation.
© by Informa Healthcare USA, Inc.
Keyword Toxicology
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Book Chapter
Collections: Official 2011 Collection
School of Medicine Publications
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Created: Sat, 19 Mar 2011, 09:59:17 EST by Professor Michael Roberts on behalf of Medicine - Princess Alexandra Hospital