A compact mock circulation loop for the in vitro testing of cardiovascular devices

Timms, Daniel L., Gregory, Shaun D., Greatrex, Nicholas A., Pearcy, Mark J., Fraser, John F. and Steinseifer, Ulrich (2011) A compact mock circulation loop for the in vitro testing of cardiovascular devices. Artificial Organs, 35 4: 384-391. doi:10.1111/j.1525-1594.2010.01088.x

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Author Timms, Daniel L.
Gregory, Shaun D.
Greatrex, Nicholas A.
Pearcy, Mark J.
Fraser, John F.
Steinseifer, Ulrich
Title A compact mock circulation loop for the in vitro testing of cardiovascular devices
Journal name Artificial Organs   Check publisher's open access policy
ISSN 0160-564X
Publication date 2011-04-01
Year available 2010
Sub-type Article (original research)
DOI 10.1111/j.1525-1594.2010.01088.x
Open Access Status DOI
Volume 35
Issue 4
Start page 384
End page 391
Total pages 8
Place of publication Cambridge, England
Publisher Blackwell Science
Language eng
Abstract In vitro cardiovascular device performance evaluation in a mock circulation loop (MCL) is a necessary step prior to in vivo testing. A MCL that accurately represents the physiology of the cardiovascular system accelerates the assessment of the device's ability to treat pathological conditions. To serve this purpose, a compact MCL measuring 600 × 600 × 600 mm (L × W × H) was constructed in conjunction with a computer mathematical simulation. This approach allowed the effective selection of physical loop characteristics, such as pneumatic drive parameters, to create pressure and flow, and pipe dimensions to replicate the resistance, compliance, and fluid inertia of the native cardiovascular system. The resulting five-element MCL reproduced the physiological hemodynamics of a healthy and failing heart by altering ventricle contractility, vascular resistance/compliance, heart rate, and vascular volume. The effects of interpatient anatomical variability, such as septal defects and valvular disease, were also assessed. Cardiovascular hemodynamic pressures (arterial, venous, atrial, ventricular), flows (systemic, bronchial, pulmonary), and volumes (ventricular, stroke) were analyzed in real time. The objective of this study is to describe the developmental stages of the compact MCL and demonstrate its value as a research tool for the accelerated development of cardiovascular devices.
Keyword Mock circulation loop
Heart disease
Cardiovascular system
Device testing
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID FRC0207-33
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Created: Thu, 17 Mar 2011, 21:41:45 EST by Debbie Banks on behalf of School of Medicine