Contrast cchocardiography in Australian clinical practice

Hamilton-Craig, Christian, Boga, Tau, West, Cathy, Kelly, Natalie, Anscombe, Russell, Burstow, Darryl and Platts, David (2010) Contrast cchocardiography in Australian clinical practice. Heart, Lung and Circulation, 19 7: 385-394. doi:10.1016/j.hlc.2010.02.001

Author Hamilton-Craig, Christian
Boga, Tau
West, Cathy
Kelly, Natalie
Anscombe, Russell
Burstow, Darryl
Platts, David
Title Contrast cchocardiography in Australian clinical practice
Journal name Heart, Lung and Circulation   Check publisher's open access policy
ISSN 1443-9506
Publication date 2010-07-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.hlc.2010.02.001
Open Access Status Not Open Access
Volume 19
Issue 7
Start page 385
End page 394
Total pages 10
Place of publication Chatswood, NSW, Australia
Publisher Elsevier Australia
Language eng
Abstract To estimate the incidence of women with vasa previa in Australia and to describe risk factors, timing of diagnosis, clinical practice, and perinatal outcomes.
Formatted abstract
The second-generation contrast agent Definity® (a perflutren microsphere) became available in Australia in mid-2007. We describe the introduction of contrast echocardiography into a high-volume quaternary teaching hospital, performing over 16,000 echocardiograms per year. Workflow protocols were developed for patient selection, contrast administration, and image acquisition and analysis.


Data were prospectively collected for all contrast cases. Endocardial definition scores were derived by three independent observers before and after contrast administration, and statistically compared.


161 patients received contrast in the first 12 months of the contrast program. There was statistically significant improvement in endocardial definition scores after contrast administration (p= 0.0001), and reduction in inter-observer variability of wall motion assessment. A number of clinically significant findings (pseudoaneurysm, non-compaction, thrombus) were detected on contrast echo that were not apparent on standard 2D imaging. Adverse events were rare (0.6%) with no life-threatening events.


The introduction of a second-generation contrast agent into clinical workflow in a hospital echocardiography department resulted in a statistically significant improvement in endocardial definition, and safely provided diagnostic imaging in cases which were otherwise non-diagnostic. Inter-observer variability was reduced, and diagnostic yield increased. These results reflect previously published data, and indicate that contrast echocardiography is feasible in Australian clinical practice.

Keyword Contrast echocardiography
Mechanical index
Left ventricular opacification
Myocardial Contrast Echocardiography (MCE)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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