Characterization of the koala biovar of Chlamydia pneumoniae at four gene loci - ompAVD4 ompB, 16S rRNA, groESL spacer region

Wardrop, S., Fowler, A., O'Callaghan, ., Giffard, P. and Timms, P. (1999) Characterization of the koala biovar of Chlamydia pneumoniae at four gene loci - ompAVD4 ompB, 16S rRNA, groESL spacer region. Systematic and Applied Microbiology, 22 1: 22-27.

Author Wardrop, S.
Fowler, A.
O'Callaghan, .
Giffard, P.
Timms, P.
Title Characterization of the koala biovar of Chlamydia pneumoniae at four gene loci - ompAVD4 ompB, 16S rRNA, groESL spacer region
Journal name Systematic and Applied Microbiology   Check publisher's open access policy
ISSN 0723-2020
1618-0984
Publication date 1999-02-01
Sub-type Article (original research)
Volume 22
Issue 1
Start page 22
End page 27
Total pages 6
Place of publication Jena, Germany
Publisher Urban und Fischer
Language eng
Abstract Koalas are infected with two species of Chlamydia, C. pecorum and C. pneumoniae. While it is known that significant generic diversity occurs in the C. pecorum strains infecting koalas, very little is known about the C. pneumoniae strains that infect this host. In the current study, 10 isolates of koala C. pneumoniae were analysed at four gene loci and found to be different to both the human and horse C. pneumoniae strains at all loci (biovar differences ranging from 0.3% at groESL up to 9.0% at ompAVD4). All koala biovar isolates studied were found to be 100% identical at ompAVD4 (all 10 isolates) and at ompB (all three isolates) genes. This lack of allelic polymorphisms at ompAVD4 has now been observed for koala C. pneumoniae, human C. pneumoniae, guinea pig inclusion conjuctivitis C. psittaci and feline conjuctivitis C. psittaci and may be correlated to a lack of antibody response to the chlamydial major outer membrane protein (MOMP) in these same strain/host combinations. This study also provides the first documented case of natural C. pneumoniae infection causing a severe and extended respiratory episode in a caprice koala population. This captive episode is in contrast to most free-range observations in which koala C. pneumoniae is rarely documented as causing respiratory, ocular or urogenital tract disease.
Keyword Koala
Chlamydia pneumoniae
OmpAVD4
OmpB
16S rRNA
Clonal
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Tue, 15 Mar 2011, 17:47:53 EST