Unstable angina: A comparison of angioscopic findings between diabetic and nondiabetic patients

Silva, Jose A., Escobar, Alvaro, Collins, Tyrone J., Ramee, Stephen R. and White, Christopher J. (1995) Unstable angina: A comparison of angioscopic findings between diabetic and nondiabetic patients. Circulation, 92 7: 1731-1736. doi:10.1161/01.CIR.92.7.1731


Author Silva, Jose A.
Escobar, Alvaro
Collins, Tyrone J.
Ramee, Stephen R.
White, Christopher J.
Title Unstable angina: A comparison of angioscopic findings between diabetic and nondiabetic patients
Journal name Circulation   Check publisher's open access policy
ISSN 0009-7322
Publication date 1995-10-01
Sub-type Article (original research)
DOI 10.1161/01.CIR.92.7.1731
Volume 92
Issue 7
Start page 1731
End page 1736
Total pages 6
Place of publication Baltimore, MD, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Background Patients with diabetes mellitus have a higher prevalence of atherosclerotic heart disease and a higher incidence of myocardial infarction than the general population. Diabetic patients also have several hematologic, rheologic, and metabolic abnormalities not present in their nondiabetic counterparts that may predispose them to atherosclerotic plaque rupture and intraluminal thrombosis and consequently may lead to the formation of morphologically complex plaques and the development of acute coronary syndromes.
Methods and Results Percutaneous coronary angioscopy was performed in 55 consecutive patients with unstable angina. We observed plaque color, texture, and the incidence of intracoronary thrombus associated with the culprit lesions of these patients. The population consisted of 17 (31%) diabetic and 38 (69%) nondiabetic patients. The presence of coronary risk factors was not significantly different between the two populations. Ulcerated plaque was found in 16 of 17 (94%) diabetic patients versus 23 of 38 (60%) nondiabetic patients (P=.01). Intracoronary thrombi were seen in 16 of 17 (94%) diabetic patients versus 21 of 38 (55%) nondiabetic patients (P=.004).
Conclusions The results of the angioscopic examination show that diabetic patients with unstable angina have a higher incidence of plaque ulceration and intracoronary thrombus formation than nondiabetic patients. This increased frequency of complex lesion morphology is consistent with the disproportionately higher risk for development of acute coronary syndromes in these patients.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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