Cardiovascular effects and regional blood flow distribution associated with angiotensin converting enzyme inhibition (captopril) in essential hypertension

Ventura, H. O., Frohlich, E. D., Messerli, F. H., Kobrin, I. and Kardon, M. B. (1985) Cardiovascular effects and regional blood flow distribution associated with angiotensin converting enzyme inhibition (captopril) in essential hypertension. American Journal of Cardiology, 55 8: 1023-1026. doi:10.1016/0002-9149(85)90739-8


Author Ventura, H. O.
Frohlich, E. D.
Messerli, F. H.
Kobrin, I.
Kardon, M. B.
Title Cardiovascular effects and regional blood flow distribution associated with angiotensin converting enzyme inhibition (captopril) in essential hypertension
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
Publication date 1985-01-01
Year available 1985
Sub-type Article (original research)
DOI 10.1016/0002-9149(85)90739-8
Open Access Status Not yet assessed
Volume 55
Issue 8
Start page 1023
End page 1026
Total pages 4
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Abstract Systemic and regional hemodynamics and cardiac structural changes were studied in 12 patients with mild to moderately severe essential hypertension before and then 90 minutes and 12 weeks after administration of captopril. Mean arterial pressure was reduced from 111 mm Hg to 96 mm Hg (p < 0.001), and this was mediated through a fall in total peripheral resistance from 26 ± 2 units to 23 ± 2 units (p < 0.01). The decreaseed total peripheral resistance was distributed to all circulations studied: kidney, skeletal muscle, skin and the splanchnic organs. Furthermore, left ventricular (LV) mass index diminished without altering myocardial contractility at rest. Thus, captopril lowered arterial pressure through systemic arteriolar dilatation in patients with mild to moderately severe essential hypertension and also reduced LV mass even in patients without evidence of LV hypertrophy.
Keyword Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
CARDIAC & CARDIOVASCULAR SYSTEMS
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 20:16:37 EST