Dimorphic cardiac adaptation to obesity and arterial hypertension

Messerli, Franz H., Sundgaard-Riise, Kirsten, Reisin, Efrain D., Dreslinski, Gerald R., Ventura, Hector O., Oigman, Willie, Frohlich, Edward D. and Dunn, Francis G. (1983) Dimorphic cardiac adaptation to obesity and arterial hypertension. Annals of Internal Medicine, 99 6: 757-761.

Author Messerli, Franz H.
Sundgaard-Riise, Kirsten
Reisin, Efrain D.
Dreslinski, Gerald R.
Ventura, Hector O.
Oigman, Willie
Frohlich, Edward D.
Dunn, Francis G.
Title Dimorphic cardiac adaptation to obesity and arterial hypertension
Journal name Annals of Internal Medicine   Check publisher's open access policy
ISSN 0003-4819
Publication date 1983-01-01
Year available 1983
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 99
Issue 6
Start page 757
End page 761
Total pages 5
Language eng
Abstract Cardiovascular function and structure were evaluated by M-mode echocardiography and systemic hemodynamics in paired lean and obese patients, either hypertensive or normotensive. Compared to lean patients, obese patients had greater left atrial (p < 0.0001), ventricular (p < 0.001), and aortic root (p < 0.002) diameters; posterior and septal wall thickness (p < 0.001); and ventricular mass, cardiac output, stroke volume, and stroke work (all p < 0.0001). Hypertensive patients had increased posterior wall thickness, end diastolic wall stress, stroke work (p < 0.01), and a lower radius to posterior wall thickness ratio indicating concentric hypertrophy (P < 0.001) when compared to normotensive patients. Cardiac adaptation to obesity consists of left ventricular dilatation and hypertrophy (eccentric hypertrophy) irrespective of arterial pressure levels. In contrast, essential hypertension solely produces concentric hypertrophy. Both obesity and hypertension increase left ventricular stroke work by disparate hemodynamic mechanisms; their presence in the same patient will tax the heart and increase the long-term risk of congestive failure.
Keyword Medicine, General & Internal
General & Internal Medicine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 20:12:32 EST