Allograft aortopathy: An in vivo study of donor aorta involvement in cardiac allograft vasculopathy

Mehra, Mandeep R., Ventura, Hector O., Stapleton, Dwight D., Karsan, Arun K., Smart, Frank W., Ramee, Stephen R. and Collins, Tyrone J. (1997) Allograft aortopathy: An in vivo study of donor aorta involvement in cardiac allograft vasculopathy. American Heart Journal, 133 6: 698-702. doi:10.1016/S0002-8703(97)70172-8


Author Mehra, Mandeep R.
Ventura, Hector O.
Stapleton, Dwight D.
Karsan, Arun K.
Smart, Frank W.
Ramee, Stephen R.
Collins, Tyrone J.
Title Allograft aortopathy: An in vivo study of donor aorta involvement in cardiac allograft vasculopathy
Journal name American Heart Journal   Check publisher's open access policy
ISSN 0002-8703
Publication date 1997-06-01
Year available 1997
Sub-type Article (original research)
DOI 10.1016/S0002-8703(97)70172-8
Open Access Status Not Open Access
Volume 133
Issue 6
Start page 698
End page 702
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Limited histopathologic studies of failed cardiac allografts have demonstrated that cardiac allograft vasculopathy extends into the donor aorta; however, no study has examined the development of allograft aortic intimal proliferation in vivo in conjunction with coronary intimal hyperplasia. By using simultaneous intracoronary and intraaortic ultrasound, we studied 20 consecutive heart transplant recipients at 2.5 ± 2.1 years after transplantation. The degree of coronary intimal thickening was strongly correlated with the development of intraaortic intimal hyperplasia ( r = 0.90; p < 0.0001). Multivariate predictors of aortic intimal thickening included years after transplant ( r = 0.47; p = 0.03), serum cholesterol level ( r = 0.65, p = 0.003), and serum triglyceride level ( r = 0.51; p = 0.03). Allograft aortopathy occurs in a similar manner to allograft coronary disease, thus providing support for the notion that an immunologic stimulus operating across the allograft vascular bed may be responsible for the development of cardiac allograft vasculopathy. Furthermore, this investigation provides insight into the putative role of hyperlipidemia in allograft vascular disease.
Keyword Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
CARDIAC & CARDIOVASCULAR SYSTEMS
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 20:11:58 EST