Immediate hemodynamic effects of urapidil in patients with essential hypertension

Kobrin, Issac, Amodeo, Celso, Ventura, Hector O., Messerli, Franz H. and Frohlich, Edward D. (1985) Immediate hemodynamic effects of urapidil in patients with essential hypertension. American Journal of Cardiology, 55 6: 722-725. doi:10.1016/0002-9149(85)90144-4

Author Kobrin, Issac
Amodeo, Celso
Ventura, Hector O.
Messerli, Franz H.
Frohlich, Edward D.
Title Immediate hemodynamic effects of urapidil in patients with essential hypertension
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
Publication date 1985-01-01
Year available 1985
Sub-type Article (original research)
DOI 10.1016/0002-9149(85)90144-4
Open Access Status Not Open Access
Volume 55
Issue 6
Start page 722
End page 725
Total pages 4
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Abstract Systemic, renal and splanchnic hemodynamics and certain reflex and endocrine responses were determined in 10 patients with essential hypertension before and after intravenous administration of urapidil, a new antihypertensive agent that acts through both central and peripheral α-adrenergic inhibitory mechanisms. The reduction in mean arterial pressure by 12% (103 ± 3 vs 91 ± 6 mm Hg, p < 0.05) was mediated through a decreased total peripheral resistance index (from 34 ± 2 to 25 ± 3 U/m2, p < 0.01), which was associated with a significant reflexive increase in cardiac index, heart rate and serum norepinephrine level. This hypotensive effect was also associated with blunted Valsalva overshoot and orthostatic hypotension, suggesting peripheral arteriolar and venular dilation. Renal and splanchnic blood flows increased (p < 0.05), resistances in these vascular beds decreased (p < 0.01) and there were no changes in creatinine clearance or glomerular filtration fraction. Thus, intravenous urapidil reduced arterial pressure by decreasing total peripheral, renal and splanchnic resistances associated with maintained organ flows and increased heart rate and cardiac index.
Keyword Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 14 Mar 2011, 20:09:35 EST