Efficacy and safety of sildenafil in the evaluation of pulmonary hypertension in severe heart failure

Alaeddini, Jamshid, Uber, Patricia A., Park, Myung H., Scott, Robert L., Ventura, Hector O. and Mehra, Mandeep R. (2004) Efficacy and safety of sildenafil in the evaluation of pulmonary hypertension in severe heart failure. American Journal of Cardiology, 94 11: 1475-1477. doi:10.1016/j.amjcard.2004.07.157


Author Alaeddini, Jamshid
Uber, Patricia A.
Park, Myung H.
Scott, Robert L.
Ventura, Hector O.
Mehra, Mandeep R.
Title Efficacy and safety of sildenafil in the evaluation of pulmonary hypertension in severe heart failure
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
1879-1913
Publication date 2004-12-01
Sub-type Article (original research)
DOI 10.1016/j.amjcard.2004.07.157
Volume 94
Issue 11
Start page 1475
End page 1477
Total pages 3
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Formatted abstract
This study sought to evaluate the utility of sildenafil in assessing pulmonary artery reactivity in left-sided cardiac failure and secondary pulmonary hypertension (PH). Fourteen consecutive patients with heart failure were studied, with oral doses of either sildenafil 25 mg (n = 8) or 50 mg (n = 6) every 8 hours for ≤3 doses, and invasive serial hemodynamic measurements were performed. Thirteen patients (93%) demonstrated >20% decreases in pulmonary artery pressures. There was also a 20% reduction of the pulmonary vascular resistance/systemic vascular resistance ratio, indicating relative pulmonary artery selectivity. Compared with sildenafil 25 mg, sildenafil 50 mg demonstrated greater reductions of pulmonary pressures. Oral sildenafil is safe and effective for the evaluation of PH reactivity in heart failure.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 20:07:11 EST