Improved cartilage repair after treatment with low-intensity pulsed ultrasound

Cook, Stephen D., Salkeld, Samantha L., Popich-Patron, Laura S., Ryaby, John P., Jones, Deryk G. and Barrack, Robert L. (2001) Improved cartilage repair after treatment with low-intensity pulsed ultrasound. Clinical Orthopaedics and Related Research, 391: S231-S243.

Author Cook, Stephen D.
Salkeld, Samantha L.
Popich-Patron, Laura S.
Ryaby, John P.
Jones, Deryk G.
Barrack, Robert L.
Title Improved cartilage repair after treatment with low-intensity pulsed ultrasound
Journal name Clinical Orthopaedics and Related Research   Check publisher's open access policy
ISSN 0009-921X
Publication date 2001-10-01
Year available 2001
Sub-type Article (original research)
Open Access Status Not yet assessed
Issue 391
Start page S231
End page S243
Total pages 13
Place of publication New York, NY, United States
Publisher Springer
Language eng
Abstract Low-intensity pulsed ultrasound accelerates bone healing via upregulation of cartilage formation and maturation phases of endchondral bone formation. The current authors evaluated the effect of ultrasound therapy on the repair of full-thickness osteochondral defects. Bilateral, 3.2 mm diameter by 5.0 mm deep osteochondral defects were created in the patellar groove of 106 adult male New Zealand rabbits. The defects were treated with daily low-intensity pulsed ultrasound therapy on the right knee. The left knee was not treated. In Part I, the effect of ultrasound therapy was evaluated at 4, 8, 12, 24, and 52 weeks after surgery. In Part II, the effect of the length of treatment (5, 10, or 40 minutes of daily ultrasound therapy) compared with standard 20 minute therapy was evaluated. The repair cartilage was evaluated and graded on a standard scale for the gross and histologic appearance. Ultrasound treatment significantly improved the morphologic features and histologic characteristics of the repair cartilage compared with nontreated controls. Earlier, better repair with less degenerative changes at later times was observed in defects treated with ultrasound. Doubling the treatment time to 40 minutes daily significantly increased the histologic quality of the repair cartilage. In the current animal model, daily low-intensity pulsed ultrasound had a significant positive effect on the healing of osteochondral defects.
Keyword Ultrasound
Bone healing
Cartilage formation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 19:18:47 EST