Chronic renal dysfunction late after liver transplantation

Cohen, Ari J., Stegall, Mark D., Rosen, Charles B., Wiesner, Russell H., Leung, Nelson, Kremers, Walter K. and Zein, Nizar N. (2002) Chronic renal dysfunction late after liver transplantation. Liver Transplantation, 8 10: 916-921. doi:10.1053/jlts.2002.35668

Author Cohen, Ari J.
Stegall, Mark D.
Rosen, Charles B.
Wiesner, Russell H.
Leung, Nelson
Kremers, Walter K.
Zein, Nizar N.
Title Chronic renal dysfunction late after liver transplantation
Journal name Liver Transplantation   Check publisher's open access policy
ISSN 1527-6465
Publication date 2002-10-01
Sub-type Article (original research)
DOI 10.1053/jlts.2002.35668
Volume 8
Issue 10
Start page 916
End page 921
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract With the increasing success of liver transplantation, more patients are developing late complications such as renal dysfunction. The goal of the current study was to assess the prevalence of renal dysfunction years after liver transplantation and to identify patients at risk for the development of this complication. Of the 527 liver transplantations performed at our institution between April 1990 and October 1998, 353 had pretransplantation and posttransplantation glomerular filtration rate (GFR) determinations by iothalamate clearance. From this entire group, 198 patients had actual 4-year follow-up and 52 had actual 6-year follow-up. In addition, 191 of these patients had intensive follow-up with GFR measurements pretransplantation and at 1 and 3 years posttransplantation (complete follow-up group). All patients received either tacrolimus- or cyclosporine-based immunosuppression. The overall mean GFR levels in both of these groups was acceptable and was not different in cyclosporine- versus tacrolimus-based immunosuppressive regimens. Renal dysfunction was progressive, with 27.5% of patients in the intensive group having a GFR < 40 mL/min/body surface area 5 years after transplantation. GFR pretransplantation did not correlate well with late renal function; however, GFR at 1 year identified patients with subsequent renal dysfunction. The cumulative incidence of renal failure for the entire group was 6.25% at 7 years and 10% at 10 years. Renal dysfunction is a major late complication after liver transplantation. The GFR at 1 year correlates best with late renal function. Patients with a low GFR at 1 year (< 40 mL/min/BSA) are a high-risk group that might benefit from early therapeutic interventions aimed at preventing subsequent renal failure.
Keyword Renal dysfunction
Liver transplantation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 18:51:05 EST