Antibacterial-induced hepatotoxicity - Incidence, prevention and management

George, D. K. and Crawford, D. H. G. (1996) Antibacterial-induced hepatotoxicity - Incidence, prevention and management. Drug Safety, 15 1: 79-85. doi:10.2165/00002018-199615010-00007


Author George, D. K.
Crawford, D. H. G.
Title Antibacterial-induced hepatotoxicity - Incidence, prevention and management
Journal name Drug Safety   Check publisher's open access policy
ISSN 0114-5916
Publication date 1996-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2165/00002018-199615010-00007
Open Access Status Not Open Access
Volume 15
Issue 1
Start page 79
End page 85
Total pages 7
Place of publication Auckland, New Zealand
Publisher Adis International
Language eng
Abstract Hepatotoxic reactions to antibacterials are rare, occurring with an estimated frequency of between 1 and 10 per 100 000 drug prescriptions for most antibacterials. Although many antibacterial-induced hepatotoxic reactions have a characteristic clinical and biochemical pattern e.g. cholestatic hepatitis (flucloxacillin) or fatty liver (tetracycline), many can also present with a variety of clinicopathological patterns e.g, nitrofurantoin is associated with the development of acute hepatitis, granulomatous hepatitis and chronic active hepatitis. Almost all reactions are idiosyncratic, with no diagnostic laboratory tests to aid the diagnosis. Early diagnosis is essential and requires a vigilant physician to elicit a detailed drug history. Although the outcome is usually good when the offending antibacterial is withdrawn, morbidity may persist for years and fatalities have occurred, particularly when there is a delay in recognising the hepatotoxic antibacterial. There is no specific treatment for antibacterial-induced hepatotoxicity other than withdrawing the implicated drug. For severe disease, however, liver transplantation should be considered.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Thu, 10 Mar 2011, 01:47:10 EST