Glomerular abnormalities in children undergoing orthotopic liver transplantation

Chin, S. E., Axelsen, R. A., Crawford, D. H. G., Endre, Z. H., Lynch, S. V., Balderson, G. A., Strong, R. W., Shepherd, R. W., Burke, J. R. and Fleming, S. J. (1992) Glomerular abnormalities in children undergoing orthotopic liver transplantation. Pediatric Nephrology, 6 5: 407-411. doi:10.1007/BF00873994

Author Chin, S. E.
Axelsen, R. A.
Crawford, D. H. G.
Endre, Z. H.
Lynch, S. V.
Balderson, G. A.
Strong, R. W.
Shepherd, R. W.
Burke, J. R.
Fleming, S. J.
Title Glomerular abnormalities in children undergoing orthotopic liver transplantation
Journal name Pediatric Nephrology   Check publisher's open access policy
ISSN 0931-041X
Publication date 1992-09-01
Sub-type Article (original research)
DOI 10.1007/BF00873994
Volume 6
Issue 5
Start page 407
End page 411
Total pages 5
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
A prospective study of renal function was undertaken on an unselected group of 8 children with chronic progressive liver disease on whom a renal biopsy was performed subsequently at the time of orthotopic liver transplantation. Two patients had abnormal urinalyses and 2 elevated urinary albumin/creatinine ratios. The remainder had no clinical evidence of renal dysfunction. All had normal serum creatinine concentrations. Glomerular abnormalities were present in all renal biopsies and were of two types: hepatic glomerulosclerosis (n=5) and minor glomerular abnormalities (n=3). IgM immunofluorescence was present in all biopsies and IgA in 6. Elevated serum immunoglobulin levels were observed in all patients, with IgM elevation in 6, IgA in 4 and IgG in 6. C3 and/or C4 were reduced in 5 patients and increased circulating immune complexes containing IgM were noted in 4. The clinical significance of these cirrhosis-associated glomerular abnormalities can only be established by long-term follow-up studies after orthotopic liver transplantation.
Keyword Glomerulonephritis
Liver cirrhosis
Orthotopic liver transplantation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 10 Mar 2011, 01:43:30 EST