Minor physical anomalies in psychoses: Associations with clinical and putative aetiological variables

McGrath, J. J., van Os, J., Hoyos, C., Jones, P. B., Harvey, I. and Murray, R. M. (1995) Minor physical anomalies in psychoses: Associations with clinical and putative aetiological variables. Schizophrenia Research, 18 1: 9-20. doi:10.1016/0920-9964(95)00016-X


Author McGrath, J. J.
van Os, J.
Hoyos, C.
Jones, P. B.
Harvey, I.
Murray, R. M.
Title Minor physical anomalies in psychoses: Associations with clinical and putative aetiological variables
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 1995-12-01
Sub-type Article (original research)
DOI 10.1016/0920-9964(95)00016-X
Volume 18
Issue 1
Start page 9
End page 20
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract This study of patients with functional psychoses set out to examine associations between minor physical anomalies (MPAs) and demographic, clinical, CT scan measures, and putative aetiological variables. 157 psychotic patients had minor physical anomalies assessed using a modified Waldrop scale. RDC diagnoses for these patients were: schizophrenia (n = 79), schizoaffective disorder (n = 31), mania (n = 24), major depression (n = 13), unspecified functional psychosis (n = 8), other organic psychosis (n = 2). 63 healthy white controls were also assessed with the modified Waldrop scale. Minor physical anomalies were not associated with any particular diagnosis. For white subjects, patients had significantly more MPAs than well controls. Anomalies of the palate were the most frequent item reported in patients and controls. For males, there was a weak association between the presence of MPAs and positive family history of a major psychiatric disorder. Those with MPAs required more frequent and longer psychiatric admissions, and showed impaired ability on a test sensitive to left parietal system function. Within the patient group, there were no associations between MPAs and gender, age at onset, negative symptoms, premorbid level of functioning, estimated premorbid intelligence, pregnancy and birth complications, and selected CT variables. Minor physical anomalies are found in a range of functional psychoses. There may be overlap between the various genes that predispose to psychiatric illness (especially in males) and those genes that predispose to developmental instability.
Keyword Minor physical anomalies
Functional psychoses
Genetics
Pregnancy
Birth complications
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Thu, 10 Mar 2011, 01:36:26 EST